Health Care Professionals (HCPs) should be immunized to protect both themselves and vulnerable patients. Health system leaders have a persuasive role in advising HCPs about influenza, and should be advocating for influenza immunization policies, including immunization being a condition of employment or appointment. The objectives of this pilot study will be to conduct interviews with a small group of Canadian health system leaders (e.g. hospital CEOs) to begin to: 1) understand leaders’ knowledge of influenza, nosocomial influenza infection by HCPs, and the current state of HCP influenza immunization rates; and 2) determine health system leaders’ attitudes, beliefs, and behaviours about new healthcare organization policies to require influenza immunization as a condition of employment or appointment for all HCPs. We will work with the CIHR-funded, Canadian Healthcare Influenza Immunization Network, the leading group conducting research on predictors of and interventions for influenza immunization among HCPs. The results of this and a planned follow-up national survey will inform recommendations to local, provincial/territorial, and federal governmental and nongovernmental organizations on policy issues related to health system leader involvement in programs requiring HCP influenza immunization, as well as future grant applications in this area.