Publications Publications
Explore our research Explorez notre recherche
CIRN has made demonstrable contributions to health and immunization research across the country. Our members are committed to quality work that bridges provinces, institutions, and disciplines. This focus on collaboration supports timely and robust research. The network’s combined insights and resources provide evidence to inform public health decision making when it matters most.
Explore our publications database below.
Le RCRI a apporté une contribution tangible à la recherche en matière de santé et de vaccination à l’échelle nationale. Nos membres sont déterminés à mener un travail de qualité qui crée des ponts entre les provinces, les établissements et les disciplines. Cette approche axée sur la collaboration favorise la réalisation de recherches rigoureuses en temps opportun. Les connaissances et les ressources combinées du réseau fournissent des données probantes qui éclairent la prise de décisions en matière de santé publique au moment où cela compte le plus.
Explorez notre base de données de publications ci-dessous.
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‘It’s really embarrassing […] to ask for help:’ navigating invisible and intersecting inequities in barriers to getting vaccinated
‘It’s really embarrassing […] to ask for help:’ navigating invisible and intersecting inequities in barriers to getting vaccinated
The arrival of COVID-19 vaccines in Canada marked the first time since the H1N1 influenza pandemic that adult vaccination became central in public health discourse, thus evoking feelings and discourse… The arrival of COVID-19 vaccines in Canada marked the first time since the H1N1 influenza pandemic that adult vaccination became central in public health discourse, thus evoking feelings and discourse…
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“ I don’t think there’s a point for me to discuss it with my patients” : exploring health care providers’ views and behaviours regarding COVID-19 vaccination
“ I don’t think there’s a point for me to discuss it with my patients” : exploring health care providers’ views and behaviours regarding COVID-19 vaccination
BACKGROUND: Health care providers’ knowledge and attitudes about vaccines are important determinants of their own vaccine uptake, their intention to recommend vaccines, and their patients’ vaccine uptake. This qualitative study’… BACKGROUND: Health care providers’ knowledge and attitudes about vaccines are important determinants of their own vaccine uptake, their intention to recommend vaccines, and their patients’ vaccine uptake. This qualitative study’…
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“ It takes time to build trust ”: a survey Ontario’s school-based HPV immunization program ten years post-implementation
“ It takes time to build trust ”: a survey Ontario’s school-based HPV immunization program ten years post-implementation
OBJECTIVES: Describe Ontario’s school-based human papillomavirus (HPV) vaccination program from the perspective of local public health units (PHUs). METHODS: In 2018, Vaccine Preventable Diseases (VPD) managers at each of Ontario’s… OBJECTIVES: Describe Ontario’s school-based human papillomavirus (HPV) vaccination program from the perspective of local public health units (PHUs). METHODS: In 2018, Vaccine Preventable Diseases (VPD) managers at each of Ontario’s…
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“The needle is already ready to go” : communities’ and health care professionals’ perceptions of routine vaccination in Nunavik, Canada
“The needle is already ready to go” : communities’ and health care professionals’ perceptions of routine vaccination in Nunavik, Canada
Inuit living in the northern region of Nunavik continue to experience significant health inequalities, which are rooted in colonialism that still have repercussions on their health-related perceptions and practices, including… Inuit living in the northern region of Nunavik continue to experience significant health inequalities, which are rooted in colonialism that still have repercussions on their health-related perceptions and practices, including…
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“Ultimately, the choice is theirs”: Informed choice vaccine conversations and Canadian midwives
“Ultimately, the choice is theirs”: Informed choice vaccine conversations and Canadian midwives
BACKGROUND: In Canada, vaccination that protects against pertussis and influenza is recommended in every pregnancy, but uptake remains low. Communicating the risks and benefits of vaccination is key to clinical… BACKGROUND: In Canada, vaccination that protects against pertussis and influenza is recommended in every pregnancy, but uptake remains low. Communicating the risks and benefits of vaccination is key to clinical…
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2017/18 and 2018/19 seasonal influenza vaccine safety surveillance, Canadian National Vaccine Safety (CANVAS) Network
2017/18 and 2018/19 seasonal influenza vaccine safety surveillance, Canadian National Vaccine Safety (CANVAS) Network
BackgroundThe Canadian National Vaccine Safety (CANVAS) network monitors the safety of seasonal influenza vaccines in Canada.AimTo provide enhanced surveillance for seasonal influenza and pandemic influenza vaccines.MethodsIn 2017/18 and 2018/19 influenza… BackgroundThe Canadian National Vaccine Safety (CANVAS) network monitors the safety of seasonal influenza vaccines in Canada.AimTo provide enhanced surveillance for seasonal influenza and pandemic influenza vaccines.MethodsIn 2017/18 and 2018/19 influenza…
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A Call for Caution in Use of Pertussis Vaccine Effectiveness Studies to Estimate Waning Immunity: A Canadian Immunization Research Network Study
A Call for Caution in Use of Pertussis Vaccine Effectiveness Studies to Estimate Waning Immunity: A Canadian Immunization Research Network Study
BACKGROUND: Vaccine effectiveness (VE) studies provide essential evidence on waning vaccine-derived immunity, a major threat to pertussis control. We evaluated how study design affects estimates by comparing 2 case-control studies… BACKGROUND: Vaccine effectiveness (VE) studies provide essential evidence on waning vaccine-derived immunity, a major threat to pertussis control. We evaluated how study design affects estimates by comparing 2 case-control studies…
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A multiprovincial retrospective analysis of the incidence of myocarditis or pericarditis after mRNA vaccination compared to the incidence after SARS-CoV-2 infection
A multiprovincial retrospective analysis of the incidence of myocarditis or pericarditis after mRNA vaccination compared to the incidence after SARS-CoV-2 infection
Objective: To compare myocarditis/pericarditis risk after COVID-19 mRNA vaccination versus SARS-CoV-2 infection, and to assess if myocarditis/pericarditis risk varies by vaccine dosing interval. Methods: In this retrospective cohort study, we… Objective: To compare myocarditis/pericarditis risk after COVID-19 mRNA vaccination versus SARS-CoV-2 infection, and to assess if myocarditis/pericarditis risk varies by vaccine dosing interval. Methods: In this retrospective cohort study, we…
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A Personalized Avatar-Based Web Application to Help People Understand How Social Distancing Can Reduce the Spread of COVID-19: Cross-sectional, Observational, Pre-Post Study
A Personalized Avatar-Based Web Application to Help People Understand How Social Distancing Can Reduce the Spread of COVID-19: Cross-sectional, Observational, Pre-Post Study
BACKGROUND: To reduce the transmission of SARS-CoV-2 and the associated spread of COVID-19, many jurisdictions around the world imposed mandatory or recommended social or physical distancing. As a result, at… BACKGROUND: To reduce the transmission of SARS-CoV-2 and the associated spread of COVID-19, many jurisdictions around the world imposed mandatory or recommended social or physical distancing. As a result, at…
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A population-based assessment of myocarditis after messenger RNA COVID-19 booster vaccination among adult recipients
A population-based assessment of myocarditis after messenger RNA COVID-19 booster vaccination among adult recipients
OBJECTIVES: We aimed to estimate the rate of myocarditis after the messenger RNA (mRNA) COVID-19 booster vaccination by vaccine type, age, and sex. METHODS: We used data from the British… OBJECTIVES: We aimed to estimate the rate of myocarditis after the messenger RNA (mRNA) COVID-19 booster vaccination by vaccine type, age, and sex. METHODS: We used data from the British…
View at publisherVoir chez l'éditeur - A randomized controlled trial of a web-based patient decision aid for COVID-19 vaccination among adults in Canada A randomized controlled trial of a web-based patient decision aid for COVID-19 vaccination among adults in Canada
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A scoping review of active, participant centred, digital adverse events following immunization (AEFI) surveillance of WHO approved COVID-19 vaccines: A Canadian immunization Research Network study
A scoping review of active, participant centred, digital adverse events following immunization (AEFI) surveillance of WHO approved COVID-19 vaccines: A Canadian immunization Research Network study
This scoping review examines the role of digital solutions in active, participant-centered surveillance of adverse events following initial release of COVID-19 vaccines. The goals of this paper were to examine… This scoping review examines the role of digital solutions in active, participant-centered surveillance of adverse events following initial release of COVID-19 vaccines. The goals of this paper were to examine…
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A scoping review of active, participant-centred, digital adverse events following immunization (AEFI) surveillance: A Canadian immunization research network study
A scoping review of active, participant-centred, digital adverse events following immunization (AEFI) surveillance: A Canadian immunization research network study
BACKGROUND: Post-licensure adverse events following immunization (AEFI) surveillance is conducted to monitor vaccine safety, such as identifying batch/brand issues and rare reactions, which consequently improves community confidence. The integration of… BACKGROUND: Post-licensure adverse events following immunization (AEFI) surveillance is conducted to monitor vaccine safety, such as identifying batch/brand issues and rare reactions, which consequently improves community confidence. The integration of…
View at publisherVoir chez l'éditeur - Acellular pertussis vaccine effectiveness and waning immunity in Alberta, Canada: 2010–2015, a Canadian Immunization Research Network (CIRN) study Acellular pertussis vaccine effectiveness and waning immunity in Alberta, Canada: 2010–2015, a Canadian Immunization Research Network (CIRN) study
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Achieving and sustaining herd immunity to SARS-CoV-2
Achieving and sustaining herd immunity to SARS-CoV-2
The herd immunity threshold is the minimum proportion of the population that must be immune to an infectious disease, usually due to vaccination, for the incidence of the disease to… The herd immunity threshold is the minimum proportion of the population that must be immune to an infectious disease, usually due to vaccination, for the incidence of the disease to…
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Adaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults ≥ 50 years: a prospective, observational cohort study
Adaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults ≥ 50 years: a prospective, observational cohort study
To evaluate immune responses to COVID-19 vaccines in adults aged 50 years and older, spike protein (S)-specific antibody concentration, avidity, and function (via angiotensin-converting enzyme 2 (ACE2) inhibition surrogate neutralization… To evaluate immune responses to COVID-19 vaccines in adults aged 50 years and older, spike protein (S)-specific antibody concentration, avidity, and function (via angiotensin-converting enzyme 2 (ACE2) inhibition surrogate neutralization…
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Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015
Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015
BACKGROUND: In Canada, 13-valent pneumococcal conjugate vaccine (PCV13) is recommended in childhood, in individuals at high risk of invasive pneumococcal disease (IPD) and in healthy adults aged ≥65 years for… BACKGROUND: In Canada, 13-valent pneumococcal conjugate vaccine (PCV13) is recommended in childhood, in individuals at high risk of invasive pneumococcal disease (IPD) and in healthy adults aged ≥65 years for…
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Agency and Amplification
Agency and Amplification
Computational techniques offer a means to overcome the amplified complexity and resource-intensity of qualitative research on online communities. However, we lack an understanding of how these techniques are integrated by… Computational techniques offer a means to overcome the amplified complexity and resource-intensity of qualitative research on online communities. However, we lack an understanding of how these techniques are integrated by…
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Agent-Based Modeling and its Tradeoffs: An Introduction & Examples
Agent-Based Modeling and its Tradeoffs: An Introduction & Examples
Agent-based modeling is a computational dynamic modeling technique that may be less familiar to some readers. Agent-based modeling seeks to understand the behaviour of complex systems by situating agents in… Agent-based modeling is a computational dynamic modeling technique that may be less familiar to some readers. Agent-based modeling seeks to understand the behaviour of complex systems by situating agents in…
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An exploration of the role of trust and rapport in enhancing vaccine uptake among Anishinaabe in rural northern Ontario
An exploration of the role of trust and rapport in enhancing vaccine uptake among Anishinaabe in rural northern Ontario
This article examines the complicated terrain of immunization acceptance and access among Indigenous peoples in northern Ontario by drawing on conversations held prior to 2019 that explored knowledge about Haemophilus… This article examines the complicated terrain of immunization acceptance and access among Indigenous peoples in northern Ontario by drawing on conversations held prior to 2019 that explored knowledge about Haemophilus…
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Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
Meningococci are bacteria that cause sepsis and meningitis. Meningococcal species are subdivided into serogroups on the basis of different sugar capsules. Vaccines that target serogroup A, C, Y, and W… Meningococci are bacteria that cause sepsis and meningitis. Meningococcal species are subdivided into serogroups on the basis of different sugar capsules. Vaccines that target serogroup A, C, Y, and W…
View at publisherVoir chez l'éditeur - Antimicrobial Prophylaxis Practices for Obstetrical Infection Prevention in Alberta: A Multi-Method Study Antimicrobial Prophylaxis Practices for Obstetrical Infection Prevention in Alberta: A Multi-Method Study
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Assessing the diagnostic accuracy of PCR-based detection of Streptococcus pneumoniae from nasopharyngeal swabs collected for viral studies in Canadian adults hospitalised with community-acquired pneumonia: a Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research (CIRN) study
Assessing the diagnostic accuracy of PCR-based detection of Streptococcus pneumoniae from nasopharyngeal swabs collected for viral studies in Canadian adults hospitalised with community-acquired pneumonia: a Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research (CIRN) study
Study design Detection and serotyping of Streptococcus pneumoniae are important to assess the impact of pneumococcal vaccines. This study describes the diagnostic accuracy of PCR-based detection of S. pneumoniae directly… Study design Detection and serotyping of Streptococcus pneumoniae are important to assess the impact of pneumococcal vaccines. This study describes the diagnostic accuracy of PCR-based detection of S. pneumoniae directly…
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Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial
Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial
BACKGROUND: The 2013–2016 Ebola virus outbreak in West Africa was the most widespread in history. In response, alive attenuated recombinant vesicular stomatitis virus (rVSV) vaccine expressing Zaire Ebolavirus glycoprotein (rVSVΔG-ZEBOV-GP)… BACKGROUND: The 2013–2016 Ebola virus outbreak in West Africa was the most widespread in history. In response, alive attenuated recombinant vesicular stomatitis virus (rVSV) vaccine expressing Zaire Ebolavirus glycoprotein (rVSVΔG-ZEBOV-GP)…
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Assessment of population immunity to measles in Ontario, Canada: a Canadian Immunization Research Network (CIRN) study
Assessment of population immunity to measles in Ontario, Canada: a Canadian Immunization Research Network (CIRN) study
Canada eliminated measles in 1998. We conducted a sero-epidemiology study to estimate population immunity to measles in the province of Ontario, Canada and to identify groups at higher risk of… Canada eliminated measles in 1998. We conducted a sero-epidemiology study to estimate population immunity to measles in the province of Ontario, Canada and to identify groups at higher risk of…
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Association between maternal mRNA covid-19 vaccination in early pregnancy and major congenital anomalies in offspring: population based cohort study with sibling matched analysis
Association between maternal mRNA covid-19 vaccination in early pregnancy and major congenital anomalies in offspring: population based cohort study with sibling matched analysis
Objective: To examine the association between maternal mRNA covid-19 vaccination during the first trimester of pregnancy and the prevalence of major congenital anomalies in offspring. Design: Population based cohort study… Objective: To examine the association between maternal mRNA covid-19 vaccination during the first trimester of pregnancy and the prevalence of major congenital anomalies in offspring. Design: Population based cohort study…
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Attitudes Toward COVID‐19 Vaccination Among Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers
Attitudes Toward COVID‐19 Vaccination Among Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers
The COVID-19 vaccine is indicated for children with acute lymphoblastic leukemia (ALL), yet patients and caregivers may have unique questions and concerns about vaccination. We surveyed children with ALL or… The COVID-19 vaccine is indicated for children with acute lymphoblastic leukemia (ALL), yet patients and caregivers may have unique questions and concerns about vaccination. We surveyed children with ALL or…
View at publisherVoir chez l'éditeur - Background incidence rates of adverse events of special interest related to COVID-19 vaccines in Ontario, Canada, 2015 to 2020, to inform COVID-19 vaccine safety surveillance Background incidence rates of adverse events of special interest related to COVID-19 vaccines in Ontario, Canada, 2015 to 2020, to inform COVID-19 vaccine safety surveillance
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Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study
OBJECTIVE: The objective of this study was to estimate background rates of selected thromboembolic and coagulation disorders in Ontario, Canada. DESIGN: Population-based retrospective observational study using linked health administrative databases.… OBJECTIVE: The objective of this study was to estimate background rates of selected thromboembolic and coagulation disorders in Ontario, Canada. DESIGN: Population-based retrospective observational study using linked health administrative databases.…
View at publisherVoir chez l'éditeur - Background rates of all-cause mortality, hospitalizations, and emergency department visits among nursing home residents in Ontario, Canada to inform COVID-19 vaccine safety assessments Background rates of all-cause mortality, hospitalizations, and emergency department visits among nursing home residents in Ontario, Canada to inform COVID-19 vaccine safety assessments
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Background rates of hospitalizations and emergency department visits for selected thromboembolic and coagulation disorders in Ontario, Canada, 2015 to 2020, to inform COVID-19 vaccine safety surveillance
Background rates of hospitalizations and emergency department visits for selected thromboembolic and coagulation disorders in Ontario, Canada, 2015 to 2020, to inform COVID-19 vaccine safety surveillance
Objective The objective of this study was to estimate background rates of selected thromboembolic and coagulation disorders in Ontario, Canada. Design Population-based retrospective observational study using linked health administrative databases.… Objective The objective of this study was to estimate background rates of selected thromboembolic and coagulation disorders in Ontario, Canada. Design Population-based retrospective observational study using linked health administrative databases.…
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Barriers, supports, and effective interventions for uptake of human papillomavirus- and other vaccines within global and Canadian Indigenous peoples: a systematic review protocol
Barriers, supports, and effective interventions for uptake of human papillomavirus- and other vaccines within global and Canadian Indigenous peoples: a systematic review protocol
BACKGROUND: Despite the existence of human papilloma virus (HPV) vaccines with demonstrated safety and effectiveness and funded HPV vaccination programs, coverage rates are persistently lower and cervical cancer burden higher… BACKGROUND: Despite the existence of human papilloma virus (HPV) vaccines with demonstrated safety and effectiveness and funded HPV vaccination programs, coverage rates are persistently lower and cervical cancer burden higher…
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Burden of Illness Associated With Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 in Infants and Young Children in Ontario, Canada, 2018–2023: A Population-Based Canadian Immunization Research Network Study
Burden of Illness Associated With Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 in Infants and Young Children in Ontario, Canada, 2018–2023: A Population-Based Canadian Immunization Research Network Study
Background: As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transitions to endemicity and respiratory syncytial virus (RSV) and influenza reestablish their seasonal circulation patterns, understanding their comparative burden on infants… Background: As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transitions to endemicity and respiratory syncytial virus (RSV) and influenza reestablish their seasonal circulation patterns, understanding their comparative burden on infants…
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Burden of vaccine-preventable pneumococcal disease in hospitalized adults: A Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) network study
Burden of vaccine-preventable pneumococcal disease in hospitalized adults: A Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) network study
BACKGROUND: ) and invasive pneumococcal disease (IPD) cause significant morbidity and mortality worldwide. Although childhood immunization programs have reduced the overall burden of pneumococcal disease, there is insufficient data in… BACKGROUND: ) and invasive pneumococcal disease (IPD) cause significant morbidity and mortality worldwide. Although childhood immunization programs have reduced the overall burden of pneumococcal disease, there is insufficient data in…
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Canadian vaccine research networks: Vaccine safety resources for Canada
Canadian vaccine research networks: Vaccine safety resources for Canada
The Public Health Agency of Canada / Canadian Institutes of Health Research Influenza Research Network (PCIRN), established in 2009 to undertake evaluative research to inform public health decision making in… The Public Health Agency of Canada / Canadian Institutes of Health Research Influenza Research Network (PCIRN), established in 2009 to undertake evaluative research to inform public health decision making in…
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CANImmunize: A digital tool to help patients manage their immunizations
CANImmunize: A digital tool to help patients manage their immunizations
A person’s immunization history is essential to health care providers to determine whether they are protected against vaccine-preventable diseases and to public health officials to ensure adequate vaccine uptake.As pharmacists… A person’s immunization history is essential to health care providers to determine whether they are protected against vaccine-preventable diseases and to public health officials to ensure adequate vaccine uptake.As pharmacists…
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Carriage of Haemophilus influenzae serotype A in children: Canadian Immunization Research Network (CIRN) study
Carriage of Haemophilus influenzae serotype A in children: Canadian Immunization Research Network (CIRN) study
Background: Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease, mainly affecting young Indigenous children. Carriage of H. influenzae is a pre-requisite for invasive… Background: Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease, mainly affecting young Indigenous children. Carriage of H. influenzae is a pre-requisite for invasive…
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Challenges and opportunities of school-based HPV vaccination in Canada
Challenges and opportunities of school-based HPV vaccination in Canada
Primary prevention of human papillomavirus (HPV) through vaccination is a high priority in Canada’s cancer prevention efforts. All Canadian provinces and territories have introduced publicly funded, school-based vaccination programs against… Primary prevention of human papillomavirus (HPV) through vaccination is a high priority in Canada’s cancer prevention efforts. All Canadian provinces and territories have introduced publicly funded, school-based vaccination programs against…
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Characteristics of individuals who received a complete, 2-dose mpox vaccine regimen as part of the public health response to the mpox epidemic in Ontario, Canada
Characteristics of individuals who received a complete, 2-dose mpox vaccine regimen as part of the public health response to the mpox epidemic in Ontario, Canada
In May 2022, an outbreak of mpox emerged in Canada. In June 2022, the province of Ontario began offering first doses of a 2-dose regimen of Modified Vaccinia Ankara-Bavaria Nordic… In May 2022, an outbreak of mpox emerged in Canada. In June 2022, the province of Ontario began offering first doses of a 2-dose regimen of Modified Vaccinia Ankara-Bavaria Nordic…
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Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study
Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study
During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the… During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the…
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Characterization of vaccine confidence among teachers in British Columbia, Canada: A population-based survey
Characterization of vaccine confidence among teachers in British Columbia, Canada: A population-based survey
OBJECTIVES: Teachers are an important occupational group to consider when addressing vaccine confidence and uptake for school-aged children due to their proximate role within school-based immunization programs. The objectives of… OBJECTIVES: Teachers are an important occupational group to consider when addressing vaccine confidence and uptake for school-aged children due to their proximate role within school-based immunization programs. The objectives of…
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Community organization perspectives on COVID-19 vaccine hesitancy and how they increased COVID-19 vaccine confidence: a Canadian Immunization Research Network, social sciences and humanities network study
Community organization perspectives on COVID-19 vaccine hesitancy and how they increased COVID-19 vaccine confidence: a Canadian Immunization Research Network, social sciences and humanities network study
Background: COVID-19 vaccines play a critical role in reducing the morbidity and mortality associated with SARS-CoV-2 infection and despite vaccine availability, disparities in COVID-19 vaccine uptake among Canadian subgroups exist.… Background: COVID-19 vaccines play a critical role in reducing the morbidity and mortality associated with SARS-CoV-2 infection and despite vaccine availability, disparities in COVID-19 vaccine uptake among Canadian subgroups exist.…
View at publisherVoir chez l'éditeur - Comparison of two automated methods for detection and differentiation of herpes simplex virus in clinical specimens Comparison of two automated methods for detection and differentiation of herpes simplex virus in clinical specimens
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Considering the impact of vaccine communication in the COVID-19 pandemic among adults in Canada: A qualitative study of lessons learned for future vaccine campaigns
Considering the impact of vaccine communication in the COVID-19 pandemic among adults in Canada: A qualitative study of lessons learned for future vaccine campaigns
We aimed to understand how experiences with vaccine-related information and communication challenges during the COVID-19 pandemic impacted motivations and behaviors among Canadian adults regarding future vaccines. Semi-structured interviews were conducted… We aimed to understand how experiences with vaccine-related information and communication challenges during the COVID-19 pandemic impacted motivations and behaviors among Canadian adults regarding future vaccines. Semi-structured interviews were conducted…
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Continuing surveillance of invasive Haemophilus influenzae disease in northwestern Ontario emphasizes the importance of serotype a and non-typeable strains as causes of serious disease: a Canadian Immunization Research Network (CIRN) Study
Continuing surveillance of invasive Haemophilus influenzae disease in northwestern Ontario emphasizes the importance of serotype a and non-typeable strains as causes of serious disease: a Canadian Immunization Research Network (CIRN) Study
In the post-Haemophilus influenzae serotype b (Hib) vaccine era, invasive H. influenzae serotype a (Hia) disease emerged in Canadian First Nation, Inuit, and Alaskan Indigenous populations. Previous studies by our… In the post-Haemophilus influenzae serotype b (Hib) vaccine era, invasive H. influenzae serotype a (Hia) disease emerged in Canadian First Nation, Inuit, and Alaskan Indigenous populations. Previous studies by our…
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Coronavirus disease 2019 vaccine effectiveness among a population-based cohort of people living with HIV
Coronavirus disease 2019 vaccine effectiveness among a population-based cohort of people living with HIV
OBJECTIVE: People with HIV were underrepresented in coronavirus disease 2019 (COVID-19) vaccine clinical trials. We estimated vaccine effectiveness (VE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for the… OBJECTIVE: People with HIV were underrepresented in coronavirus disease 2019 (COVID-19) vaccine clinical trials. We estimated vaccine effectiveness (VE) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for the…
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Cost-effectiveness analysis of nirsevimab and maternal RSVpreF vaccine strategies for prevention of Respiratory Syncytial Virus disease among infants in Canada: a simulation study
Cost-effectiveness analysis of nirsevimab and maternal RSVpreF vaccine strategies for prevention of Respiratory Syncytial Virus disease among infants in Canada: a simulation study
Background: The cost-effectiveness of immunisation strategies with a long-acting monoclonal antibody (nirsevimab) and/or a protein-based maternal vaccine (RSVpreF) for protecting infants from Respiratory Syncytial Virus (RSV)-associated illness has not been… Background: The cost-effectiveness of immunisation strategies with a long-acting monoclonal antibody (nirsevimab) and/or a protein-based maternal vaccine (RSVpreF) for protecting infants from Respiratory Syncytial Virus (RSV)-associated illness has not been…
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COVID-19 Seroprevalence in Canada Modelling Waning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network Study
COVID-19 Seroprevalence in Canada Modelling Waning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network Study
COVID-19 seroprevalence changes over time, with infection, vaccination, and waning immunity. Seroprevalence estimates are needed to determine when increased COVID-19 vaccination coverage is needed, and when booster doses should be… COVID-19 seroprevalence changes over time, with infection, vaccination, and waning immunity. Seroprevalence estimates are needed to determine when increased COVID-19 vaccination coverage is needed, and when booster doses should be…
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COVID-19 vaccination in pregnancy: How discrepant public health discourses shape responsibility for fetal health
COVID-19 vaccination in pregnancy: How discrepant public health discourses shape responsibility for fetal health
Early in COVID-19 vaccine rollout, expert recommendations about vaccination while pregnant and breastfeeding changed rapidly. This paper addresses the (re)production of gendered power relations in these expert discourses and recommendations… Early in COVID-19 vaccine rollout, expert recommendations about vaccination while pregnant and breastfeeding changed rapidly. This paper addresses the (re)production of gendered power relations in these expert discourses and recommendations…
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COVID-19 vaccine acceptance and preference for future delivery among language minority, newcomer, and racialized peoples in Canada: a national cross-sectional and longitudinal study
COVID-19 vaccine acceptance and preference for future delivery among language minority, newcomer, and racialized peoples in Canada: a national cross-sectional and longitudinal study
BACKGROUND: Despite high COVID-19 vaccine coverage in Canada, vaccine acceptance and preferred delivery among newcomers, racialized persons, and those who primarily speak minority languages are not well understood. This national… BACKGROUND: Despite high COVID-19 vaccine coverage in Canada, vaccine acceptance and preferred delivery among newcomers, racialized persons, and those who primarily speak minority languages are not well understood. This national…
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Declining rates of cervical intraepithelial neoplasia in British Columbia, Canada: An ecological analysis on the effects of the school‐based human papillomavirus vaccination program
Declining rates of cervical intraepithelial neoplasia in British Columbia, Canada: An ecological analysis on the effects of the school‐based human papillomavirus vaccination program
Since 2008, girls in British Columbia (BC), Canada, have been offered HPV vaccination through a school-based, publicly funded immunization program. The oldest birth cohort eligible for the vaccination program was… Since 2008, girls in British Columbia (BC), Canada, have been offered HPV vaccination through a school-based, publicly funded immunization program. The oldest birth cohort eligible for the vaccination program was…
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Designing tailored interventions to address barriers to vaccination
Designing tailored interventions to address barriers to vaccination
Despite efforts to promote vaccination and make vaccination services easily accessible, vaccination coverage rates remain below the target rate for many vaccines in various jurisdictions. The Tailoring Immunization Programmes (TIP)… Despite efforts to promote vaccination and make vaccination services easily accessible, vaccination coverage rates remain below the target rate for many vaccines in various jurisdictions. The Tailoring Immunization Programmes (TIP)…
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Determining the Longitudinal Serologic Response to COVID-19 Vaccination in the Chronic Kidney Disease Population: A Clinical Research Protocol
Determining the Longitudinal Serologic Response to COVID-19 Vaccination in the Chronic Kidney Disease Population: A Clinical Research Protocol
Background: People living with chronic kidney disease (CKD) have been disproportionately affected by the coronavirus disease 2019 (COVID-19) pandemic, including higher rates of infection, hospitalization, and death. Data on responsiveness… Background: People living with chronic kidney disease (CKD) have been disproportionately affected by the coronavirus disease 2019 (COVID-19) pandemic, including higher rates of infection, hospitalization, and death. Data on responsiveness…
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Developing an interactive, personalized patient decision aid for COVID-19 vaccination in Canada: Insights from a human-centered design and development study
Developing an interactive, personalized patient decision aid for COVID-19 vaccination in Canada: Insights from a human-centered design and development study
Background The COVID-19 pandemic highlighted the need for practical digital health tools to support informed decision-making amidst rapidly evolving evidence and widespread misinformation. Objective We iteratively developed and refined VaxDA-C19,… Background The COVID-19 pandemic highlighted the need for practical digital health tools to support informed decision-making amidst rapidly evolving evidence and widespread misinformation. Objective We iteratively developed and refined VaxDA-C19,…
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Digital sociology and information science research
Digital sociology and information science research
Digital sociology is a new subfield of sociology that has challenged the discipline to engage with digital methods, information practices, and questions of societal data use. Such topics have been… Digital sociology is a new subfield of sociology that has challenged the discipline to engage with digital methods, information practices, and questions of societal data use. Such topics have been…
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Does an off-label two-dose RotaTeq vaccine schedule translate into a higher incidence of rotavirus hospital admissions compared to the approved three-dose RotaTeq schedule? A Canadian immunization research network study
Does an off-label two-dose RotaTeq vaccine schedule translate into a higher incidence of rotavirus hospital admissions compared to the approved three-dose RotaTeq schedule? A Canadian immunization research network study
BACKGROUND: Rotavirus (RV) vaccination programs were implemented between 2011 and 2012 in Canada and have considerably reduced the burden of RV disease. In September 2018, the province of Quebec implemented… BACKGROUND: Rotavirus (RV) vaccination programs were implemented between 2011 and 2012 in Canada and have considerably reduced the burden of RV disease. In September 2018, the province of Quebec implemented…
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Effect of pneumococcal conjugate vaccine booster dose on prevention of invasive pneumococcal disease in British Columbia, 2003–2018
Effect of pneumococcal conjugate vaccine booster dose on prevention of invasive pneumococcal disease in British Columbia, 2003–2018
BACKGROUND: Invasive pneumococcal disease (IPD) remains a major cause of morbidity in children despite the routine use of pneumococcal conjugate vaccines (PCVs) in childhood immunization programs. While the effectiveness of… BACKGROUND: Invasive pneumococcal disease (IPD) remains a major cause of morbidity in children despite the routine use of pneumococcal conjugate vaccines (PCVs) in childhood immunization programs. While the effectiveness of…
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Effectiveness and cost-effectiveness of RSV infant and maternal immunization programs: A case study of Nunavik, Canada
Effectiveness and cost-effectiveness of RSV infant and maternal immunization programs: A case study of Nunavik, Canada
BACKGROUND: Despite passive immunization with palivizumab to select high-risk children under two years of age, the health and economic burden of respiratory syncytial virus (RSV) remains substantial. We evaluated the… BACKGROUND: Despite passive immunization with palivizumab to select high-risk children under two years of age, the health and economic burden of respiratory syncytial virus (RSV) remains substantial. We evaluated the…
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Effectiveness of BNT162b2 and mRNA-1273 COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe COVID-19 outcomes in Ontario, Canada: a test-negative design study
Effectiveness of BNT162b2 and mRNA-1273 COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe COVID-19 outcomes in Ontario, Canada: a test-negative design study
Objectives To estimate the effectiveness of mRNA COVID-19 vaccines against symptomatic infection and severe outcomes. Design We applied a test-negative design study to linked laboratory, vaccination, and health administrative databases,… Objectives To estimate the effectiveness of mRNA COVID-19 vaccines against symptomatic infection and severe outcomes. Design We applied a test-negative design study to linked laboratory, vaccination, and health administrative databases,…
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Effectiveness of Coronavirus Disease 2019 Vaccines Against Hospitalization and Death in Canada: A Multiprovincial, Test-Negative Design Study
Effectiveness of Coronavirus Disease 2019 Vaccines Against Hospitalization and Death in Canada: A Multiprovincial, Test-Negative Design Study
BACKGROUND: A major goal of coronavirus disease 2019 (COVID-19) vaccination is to prevent severe outcomes (hospitalizations and deaths). We estimated the effectiveness of messenger RNA (mRNA) and ChAdOx1 COVID-19 vaccines… BACKGROUND: A major goal of coronavirus disease 2019 (COVID-19) vaccination is to prevent severe outcomes (hospitalizations and deaths). We estimated the effectiveness of messenger RNA (mRNA) and ChAdOx1 COVID-19 vaccines…
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Effectiveness of COVID-19 vaccines against hospitalization and death in Canada: A multiprovincial test-negative design study
Effectiveness of COVID-19 vaccines against hospitalization and death in Canada: A multiprovincial test-negative design study
Background A major goal of COVID-19 vaccination is to prevent severe outcomes (hospitalizations and deaths). We estimated the effectiveness of mRNA and ChAdOx1 COVID-19 vaccines against severe outcomes in four… Background A major goal of COVID-19 vaccination is to prevent severe outcomes (hospitalizations and deaths). We estimated the effectiveness of mRNA and ChAdOx1 COVID-19 vaccines against severe outcomes in four…
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Effectiveness of COVID-19 vaccines against Omicron or Delta symptomatic infection and severe outcomes
Effectiveness of COVID-19 vaccines against Omicron or Delta symptomatic infection and severe outcomes
Background The incidence of SARS-CoV-2 infection, including among those who have received 2 doses of COVID-19 vaccines, increased substantially following the emergence of Omicron in Ontario, Canada. Methods Applying the… Background The incidence of SARS-CoV-2 infection, including among those who have received 2 doses of COVID-19 vaccines, increased substantially following the emergence of Omicron in Ontario, Canada. Methods Applying the…
View at publisherVoir chez l'éditeur - Effectiveness of COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario Effectiveness of COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario
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Effectiveness of COVID-19 Vaccines Over Time Prior to Omicron Emergence in Ontario, Canada: Test-Negative Design Study
Effectiveness of COVID-19 Vaccines Over Time Prior to Omicron Emergence in Ontario, Canada: Test-Negative Design Study
Background: Waning protection from 2 doses of coronavirus disease 2019 (COVID-19) vaccines led to third dose availability in multiple countries even before the emergence of the Omicron variant. Methods: We… Background: Waning protection from 2 doses of coronavirus disease 2019 (COVID-19) vaccines led to third dose availability in multiple countries even before the emergence of the Omicron variant. Methods: We…
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Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada
Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada
BACKGROUND: Randomized trials conducted in low- and middle-income settings demonstrated efficacy of influenza vaccination during pregnancy against influenza infection among infants BACKGROUND: Randomized trials conducted in low- and middle-income settings demonstrated efficacy of influenza vaccination during pregnancy against influenza infection among infants
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Effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine against mpox infection: emulation of a target trial
Effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine against mpox infection: emulation of a target trial
OBJECTIVE: To estimate the real world effectiveness of modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine against mpox infection. DESIGN: Emulation of a target trial. SETTING: Linked databases in Ontario, Canada. PARTICIPANTS:… OBJECTIVE: To estimate the real world effectiveness of modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine against mpox infection. DESIGN: Emulation of a target trial. SETTING: Linked databases in Ontario, Canada. PARTICIPANTS:…
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Effectiveness of mRNA and ChAdOx1 COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario
Effectiveness of mRNA and ChAdOx1 COVID-19 vaccines against symptomatic SARS-CoV-2 infection and severe outcomes with variants of concern in Ontario
SARS-CoV-2 variants of concern (VOC) are more transmissible and have the potential for increased disease severity and decreased vaccine effectiveness. We estimated the effectiveness of BNT162b2 (Pfizer-BioNTech Comirnaty), mRNA-1273 (Moderna… SARS-CoV-2 variants of concern (VOC) are more transmissible and have the potential for increased disease severity and decreased vaccine effectiveness. We estimated the effectiveness of BNT162b2 (Pfizer-BioNTech Comirnaty), mRNA-1273 (Moderna…
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Effectiveness of mRNA COVID-19 Monovalent and Bivalent Vaccine Booster Doses Against Omicron Severe Outcomes Among Adults Aged ≥50 Years in Ontario, Canada: A Canadian Immunization Research Network Study
Effectiveness of mRNA COVID-19 Monovalent and Bivalent Vaccine Booster Doses Against Omicron Severe Outcomes Among Adults Aged ≥50 Years in Ontario, Canada: A Canadian Immunization Research Network Study
We estimated the effectiveness of booster doses of monovalent and bivalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults aged ≥50 years in Ontario, Canada. Monovalent and bivalent mRNA… We estimated the effectiveness of booster doses of monovalent and bivalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults aged ≥50 years in Ontario, Canada. Monovalent and bivalent mRNA…
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Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes
Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes
We estimated the effectiveness of booster doses of monovalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a test-negative design to estimate vaccine effectiveness… We estimated the effectiveness of booster doses of monovalent mRNA COVID-19 vaccines against Omicron-associated severe outcomes among adults in Ontario, Canada. We used a test-negative design to estimate vaccine effectiveness…
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Effectiveness of one dose of MVA-BN vaccine against mpox infection in males in Ontario, Canada: A target trial emulation
Effectiveness of one dose of MVA-BN vaccine against mpox infection in males in Ontario, Canada: A target trial emulation
Background Limited evidence is available on the real-world effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN) against mpox infection. Methods We emulated a target trial using linked databases in Ontario,… Background Limited evidence is available on the real-world effectiveness of modified vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN) against mpox infection. Methods We emulated a target trial using linked databases in Ontario,…
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Enhancing HPV vaccine uptake in girls and boys – A qualitative analysis of Canadian school-based vaccination programs
Enhancing HPV vaccine uptake in girls and boys – A qualitative analysis of Canadian school-based vaccination programs
The purpose of this study was to better understand barriers and enabling conditions for HPV vaccination in school-based vaccination programs in Canada. Semi-structured interviews were conducted by telephone or in… The purpose of this study was to better understand barriers and enabling conditions for HPV vaccination in school-based vaccination programs in Canada. Semi-structured interviews were conducted by telephone or in…
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Epidemiology of pertussis in Alberta, Canada 2004–2015
Epidemiology of pertussis in Alberta, Canada 2004–2015
BACKGROUND: We describe the epidemiology of pertussis in Alberta, Canada by person, place, and time between 2004 and 2015, identify outbreak years, and examine vaccination coverage and vaccination timeliness. METHODS:… BACKGROUND: We describe the epidemiology of pertussis in Alberta, Canada by person, place, and time between 2004 and 2015, identify outbreak years, and examine vaccination coverage and vaccination timeliness. METHODS:…
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Estimated Effectiveness of COVID-19 Vaccines Against Omicron or Delta Symptomatic Infection and Severe Outcomes
Estimated Effectiveness of COVID-19 Vaccines Against Omicron or Delta Symptomatic Infection and Severe Outcomes
Importance: The incidence of SARS-CoV-2 infection, including among individuals who have received 2 doses of COVID-19 vaccine, increased substantially following the emergence of the Omicron variant in Ontario, Canada. Understanding… Importance: The incidence of SARS-CoV-2 infection, including among individuals who have received 2 doses of COVID-19 vaccine, increased substantially following the emergence of the Omicron variant in Ontario, Canada. Understanding…
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Estimating population-based incidence of community-acquired pneumonia and acute otitis media in children and adults in Ontario and British Columbia using health administrative data, 2005–2018: a Canadian Immunisation Research Network (CIRN) study
Estimating population-based incidence of community-acquired pneumonia and acute otitis media in children and adults in Ontario and British Columbia using health administrative data, 2005–2018: a Canadian Immunisation Research Network (CIRN) study
BACKGROUND: There is a paucity of data on the burden of the full spectrum of community-acquired pneumonia (CAP) and acute otitis media (AOM) from outpatient and inpatient settings across the… BACKGROUND: There is a paucity of data on the burden of the full spectrum of community-acquired pneumonia (CAP) and acute otitis media (AOM) from outpatient and inpatient settings across the…
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Evaluating the Individual Healthcare Costs and Burden of Disease Associated with RSV Across Age Groups
Evaluating the Individual Healthcare Costs and Burden of Disease Associated with RSV Across Age Groups
BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI), with high morbidity and mortality worldwide. RSV costing and burden estimates can highlight the potential benefits… BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of acute respiratory infection (ARI), with high morbidity and mortality worldwide. RSV costing and burden estimates can highlight the potential benefits…
View at publisherVoir chez l'éditeur - Evaluation of the effectiveness of maternal immunization against pertussis in Alberta using agent-based modeling: A Canadian immunization research network study Evaluation of the effectiveness of maternal immunization against pertussis in Alberta using agent-based modeling: A Canadian immunization research network study
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Examining an Altruism-Eliciting Video Intervention to Increase COVID-19 Vaccine Intentions in Younger Adults: A Qualitative Assessment Using the Realistic Evaluation Framework
Examining an Altruism-Eliciting Video Intervention to Increase COVID-19 Vaccine Intentions in Younger Adults: A Qualitative Assessment Using the Realistic Evaluation Framework
COVID-19 vaccine-induced immunity wanes over time, and with the emergence of new variants, additional “booster” doses have been recommended in Canada. However, booster vaccination uptake has remained low, particularly amongst… COVID-19 vaccine-induced immunity wanes over time, and with the emergence of new variants, additional “booster” doses have been recommended in Canada. However, booster vaccination uptake has remained low, particularly amongst…
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Exploring Clinically Meaningful Changes for the Frailty Index in a Longitudinal Cohort of Hospitalized Older Patients
Exploring Clinically Meaningful Changes for the Frailty Index in a Longitudinal Cohort of Hospitalized Older Patients
BACKGROUND: Clinically meaningful change (CMC) for frailty index (FI) scores is little studied. We estimated the CMC by associating changes in FI scores with changes in the Clinical Frailty Scale… BACKGROUND: Clinically meaningful change (CMC) for frailty index (FI) scores is little studied. We estimated the CMC by associating changes in FI scores with changes in the Clinical Frailty Scale…
View at publisherVoir chez l'éditeur - Exploring the reasons for low pertussis vaccine effectiveness in Ontario, Canada, 2006–2008: a Canadian Immunization Research Network study Exploring the reasons for low pertussis vaccine effectiveness in Ontario, Canada, 2006–2008: a Canadian Immunization Research Network study
- Factors associated with intention to receive vaccines for bacterial sexually transmitted infections among young HPV-vaccinated Canadian women Factors associated with intention to receive vaccines for bacterial sexually transmitted infections among young HPV-vaccinated Canadian women
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Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults
Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults
BACKGROUND AND OBJECTIVES: Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity… BACKGROUND AND OBJECTIVES: Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity…
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Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults
Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults
BACKGROUND Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk… BACKGROUND Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk…
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Fluorescent Cell Barcoding of Peripheral Blood Mononuclear Cells for High‐Throughput Assessment of Vaccine‐Induced T Cell Responses in Low‐Volume Research Samples
Fluorescent Cell Barcoding of Peripheral Blood Mononuclear Cells for High‐Throughput Assessment of Vaccine‐Induced T Cell Responses in Low‐Volume Research Samples
T cell responses are rarely measured in large-scale human vaccine studies due to the sample volumes required, as well as the logistical, technical, and financial challenges associated with available assays.… T cell responses are rarely measured in large-scale human vaccine studies due to the sample volumes required, as well as the logistical, technical, and financial challenges associated with available assays.…
View at publisherVoir chez l'éditeur - Future immunisation strategies to prevent Streptococcus pneumoniae infections in children and adults Future immunisation strategies to prevent Streptococcus pneumoniae infections in children and adults
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Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada
Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada
Despite the provision of a mumps vaccination program in Canada for over three decades, mumps has not reached elimination. Instead, a re-emergence has been observed in vaccinated populations, particularly in… Despite the provision of a mumps vaccination program in Canada for over three decades, mumps has not reached elimination. Instead, a re-emergence has been observed in vaccinated populations, particularly in…
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Healthcare provider awareness, attitudes, beliefs, and behaviors regarding the role of pharmacists as immunizers
Healthcare provider awareness, attitudes, beliefs, and behaviors regarding the role of pharmacists as immunizers
< .001) than pharmacists did in the multivariable analyses. Pharmacists are well-positioned and willing to vaccinate and generally have support from their nurse and physician peers, but logistical challenges and… < .001) than pharmacists did in the multivariable analyses. Pharmacists are well-positioned and willing to vaccinate and generally have support from their nurse and physician peers, but logistical challenges and…
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Healthcare providers’ awareness, attitudes, beliefs, and practices surrounding pharmacist-administered vaccination: Insights after a two-year intervention
Healthcare providers’ awareness, attitudes, beliefs, and practices surrounding pharmacist-administered vaccination: Insights after a two-year intervention
Despite the expanding scope of pharmacists’ practice to include immunization, vaccine coverage among adults in Canada remains below national targets. We conducted online surveys of healthcare providers (HCPs) that provide… Despite the expanding scope of pharmacists’ practice to include immunization, vaccine coverage among adults in Canada remains below national targets. We conducted online surveys of healthcare providers (HCPs) that provide…
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Healthcare utilization among COVID-19 mRNA vaccine-associated myocarditis cases: a matched retrospective cohort study
Healthcare utilization among COVID-19 mRNA vaccine-associated myocarditis cases: a matched retrospective cohort study
OBJECTIVES: We evaluated all-cause healthcare utilization among those with vaccine-associated myocarditis, compared to vaccinees without postvaccination myocarditis. METHODS: We conducted a retrospective cohort study in individuals aged 12 and older… OBJECTIVES: We evaluated all-cause healthcare utilization among those with vaccine-associated myocarditis, compared to vaccinees without postvaccination myocarditis. METHODS: We conducted a retrospective cohort study in individuals aged 12 and older…
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Hematologic adverse events following COVID-19 vaccination and revaccination in persons aged 12 and above: A Canadian Immunization Research Network study
Hematologic adverse events following COVID-19 vaccination and revaccination in persons aged 12 and above: A Canadian Immunization Research Network study
Data on safety of revaccination after a hematologic adverse event following immunization (AEFI) with COVID-19 vaccines are limited. This study characterized hematologic AEFIs in patients assessed by Canadian Special Immunization… Data on safety of revaccination after a hematologic adverse event following immunization (AEFI) with COVID-19 vaccines are limited. This study characterized hematologic AEFIs in patients assessed by Canadian Special Immunization…
View at publisherVoir chez l'éditeur - High-risk HPV prevalence among women undergoing cervical cancer screening: Findings a decade after HPV vaccine implementation in British Columbia, Canada High-risk HPV prevalence among women undergoing cervical cancer screening: Findings a decade after HPV vaccine implementation in British Columbia, Canada
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Highly pathogenic avian influenza: Unprecedented outbreaks in Canadian wildlife and domestic poultry
Highly pathogenic avian influenza: Unprecedented outbreaks in Canadian wildlife and domestic poultry
Canada experienced a wave of HPAI H5N1 outbreaks in the spring of 2022 with millions of wild and farmed birds being infected. Seabird mortalities in Canada have been particularly severe… Canada experienced a wave of HPAI H5N1 outbreaks in the spring of 2022 with millions of wild and farmed birds being infected. Seabird mortalities in Canada have been particularly severe…
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Hospital admissions for acute respiratory tract infections among infants from Nunavut and the burden of respiratory syncytial virus: a 10-year retrospective cohort study
Hospital admissions for acute respiratory tract infections among infants from Nunavut and the burden of respiratory syncytial virus: a 10-year retrospective cohort study
Background: Nunavut is a northern Canadian territory where a high proportion of infants are admitted to hospital with acute respiratory tract infection (ARI). Previous studies have been limited in regional… Background: Nunavut is a northern Canadian territory where a high proportion of infants are admitted to hospital with acute respiratory tract infection (ARI). Previous studies have been limited in regional…
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How well do ICD-9 physician claim diagnostic codes identify confirmed pertussis cases in Alberta, Canada? A Canadian Immunization Research Network (CIRN) Study
How well do ICD-9 physician claim diagnostic codes identify confirmed pertussis cases in Alberta, Canada? A Canadian Immunization Research Network (CIRN) Study
BACKGROUND: Rates of Bordetella pertussis have been increasing in Alberta, Canada despite vaccination programs. Waning immunity from existing acellular component vaccines may be contributing to this. Vaccine effectiveness can be… BACKGROUND: Rates of Bordetella pertussis have been increasing in Alberta, Canada despite vaccination programs. Waning immunity from existing acellular component vaccines may be contributing to this. Vaccine effectiveness can be…
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HPV prevalence, vaccination coverage and intention to get vaccinated among gay, bisexual, and other men who have sex with men: Evaluation of Quebec’s (Canada) HPV vaccination program
HPV prevalence, vaccination coverage and intention to get vaccinated among gay, bisexual, and other men who have sex with men: Evaluation of Quebec’s (Canada) HPV vaccination program
Objectives In Quebec, Canada, vaccination against human papillomavirus (HPV) has been publicly-funded since January 2016 for gay, bisexual, and other men who have sex with men (GBM) aged ≤26 years.… Objectives In Quebec, Canada, vaccination against human papillomavirus (HPV) has been publicly-funded since January 2016 for gay, bisexual, and other men who have sex with men (GBM) aged ≤26 years.…
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Human Papillomavirus (HPV) Vaccination Among Gay, Bisexual, and Other Men Who Have Sex with Men and Men Living with HIV
Human Papillomavirus (HPV) Vaccination Among Gay, Bisexual, and Other Men Who Have Sex with Men and Men Living with HIV
Gay, bisexual, and other men who have sex with men (GBM) and men living with HIV are disproportionately affected by HPV compared to the general population. The Canadian National Advisory… Gay, bisexual, and other men who have sex with men (GBM) and men living with HIV are disproportionately affected by HPV compared to the general population. The Canadian National Advisory…
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Human papillomavirus (HPV) vaccine coverage and associated sociodemographic factors among individuals eligible for publicly funded vaccine in Ontario, Canada from 2007 to 2023: A Canadian immunization research network study
Human papillomavirus (HPV) vaccine coverage and associated sociodemographic factors among individuals eligible for publicly funded vaccine in Ontario, Canada from 2007 to 2023: A Canadian immunization research network study
BACKGROUND: Publicly funded human papillomavirus (HPV) vaccination programs are available for school-aged children to help prevent HPV-associated cancers and other outcomes, with goals of reaching 90% coverage (≥2 doses) in… BACKGROUND: Publicly funded human papillomavirus (HPV) vaccination programs are available for school-aged children to help prevent HPV-associated cancers and other outcomes, with goals of reaching 90% coverage (≥2 doses) in…
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Human papillomavirus (HPV) vaccine uptake among a community-recruited sample of gay, bisexual, and other men who have sex with men in the three largest cities in Canada from 2017 to 2019
Human papillomavirus (HPV) vaccine uptake among a community-recruited sample of gay, bisexual, and other men who have sex with men in the three largest cities in Canada from 2017 to 2019
INTRODUCTION: In 2015/2016, Canada’s largest provinces implemented publicly-funded human papillomavirus (HPV) vaccination programs for gay, bisexual, and other men who have sex with men (GBM) ≤ 26 years old. We… INTRODUCTION: In 2015/2016, Canada’s largest provinces implemented publicly-funded human papillomavirus (HPV) vaccination programs for gay, bisexual, and other men who have sex with men (GBM) ≤ 26 years old. We…
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Humoral immunity to endemic coronaviruses in older adults increases post-COVID-19 vaccination and in correlation with their anti-SARS-CoV-2 responses
Humoral immunity to endemic coronaviruses in older adults increases post-COVID-19 vaccination and in correlation with their anti-SARS-CoV-2 responses
Advanced age is an established risk factor for SARS-CoV-2 infection and severe disease. Older adults, having experienced recurrent infections with human endemic coronaviruses (HCoVs) throughout life, may have developed humoral… Advanced age is an established risk factor for SARS-CoV-2 infection and severe disease. Older adults, having experienced recurrent infections with human endemic coronaviruses (HCoVs) throughout life, may have developed humoral…
View at publisherVoir chez l'éditeur - Immunization information systems in Canada: Attributes, functionality, strengths and challenges. A Canadian Immunization Research Network study Immunization information systems in Canada: Attributes, functionality, strengths and challenges. A Canadian Immunization Research Network study
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Immunogenicity and Safety of Live Attenuated Varicella Vaccine in Children and Youth With Solid Organ Transplants in Canada: A Canadian Immunization Research Network Study
Immunogenicity and Safety of Live Attenuated Varicella Vaccine in Children and Youth With Solid Organ Transplants in Canada: A Canadian Immunization Research Network Study
INTRODUCTION: Children with solid organ transplants (SOT) face higher risks of severe disease from varicella-zoster virus (VZV). Although some guidelines recommend live attenuated varicella vaccine (LAVV) for select children post… INTRODUCTION: Children with solid organ transplants (SOT) face higher risks of severe disease from varicella-zoster virus (VZV). Although some guidelines recommend live attenuated varicella vaccine (LAVV) for select children post…
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Immunogenicity of 2 and 3 Doses of the Quadrivalent Human Papillomavirus Vaccine up to 120 Months Postvaccination: Follow-up of a Randomized Clinical Trial
Immunogenicity of 2 and 3 Doses of the Quadrivalent Human Papillomavirus Vaccine up to 120 Months Postvaccination: Follow-up of a Randomized Clinical Trial
BACKGROUND: Several countries have implemented a 2-dose (2D) human papillomavirus (HPV) vaccination schedule for adolescents based on immunobridging studies. We compared immunogenicity of 2D vs 3-dose (3D) schedules of the… BACKGROUND: Several countries have implemented a 2-dose (2D) human papillomavirus (HPV) vaccination schedule for adolescents based on immunobridging studies. We compared immunogenicity of 2D vs 3-dose (3D) schedules of the…
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Impact and cost-effectiveness analyses of vaccination for prevention of respiratory syncytial virus disease among older adults in Ontario: A Canadian Immunization Research Network (CIRN) study
Impact and cost-effectiveness analyses of vaccination for prevention of respiratory syncytial virus disease among older adults in Ontario: A Canadian Immunization Research Network (CIRN) study
BACKGROUND: Two prefusion F protein-based vaccines, Arexvy and Abrysvo, have been approved by Health Canada for protecting older adults against respiratory syncytial virus (RSV)-associated lower respiratory tract disease. We estimated… BACKGROUND: Two prefusion F protein-based vaccines, Arexvy and Abrysvo, have been approved by Health Canada for protecting older adults against respiratory syncytial virus (RSV)-associated lower respiratory tract disease. We estimated…
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Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Understanding the key drivers of SARS-CoV-2 transmission is essential for shaping effective public health strategies. However, transmission risk is subject to substantial heterogeneity related to disease severity, age, sex, comorbidities,… Understanding the key drivers of SARS-CoV-2 transmission is essential for shaping effective public health strategies. However, transmission risk is subject to substantial heterogeneity related to disease severity, age, sex, comorbidities,…
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Impact of non-pharmaceutical interventions and vaccination on COVID-19 outbreaks in Nunavut, Canada: a Canadian Immunization Research Network (CIRN) study
Impact of non-pharmaceutical interventions and vaccination on COVID-19 outbreaks in Nunavut, Canada: a Canadian Immunization Research Network (CIRN) study
BACKGROUND: Nunavut, the northernmost Arctic territory of Canada, experienced three community outbreaks of the coronavirus disease 2019 (COVID-19) from early November 2020 to mid-June 2021. We sought to investigate how… BACKGROUND: Nunavut, the northernmost Arctic territory of Canada, experienced three community outbreaks of the coronavirus disease 2019 (COVID-19) from early November 2020 to mid-June 2021. We sought to investigate how…
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Impact of recruitment strategies on individual participation practices in the Canadian National Vaccine Safety Network: prospective cohort study
Impact of recruitment strategies on individual participation practices in the Canadian National Vaccine Safety Network: prospective cohort study
Background: The Canadian National Vaccine Safety (CANVAS) network conducted a multi-center, prospective vaccine safety study to collect safety data after dose 1 and 2 of COVID-19 vaccines and follow up… Background: The Canadian National Vaccine Safety (CANVAS) network conducted a multi-center, prospective vaccine safety study to collect safety data after dose 1 and 2 of COVID-19 vaccines and follow up…
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Impacts of Human Papillomavirus Immunization Programs on Rates of Anogenital Warts in British Columbia, Canada, 2000 to 2017
Impacts of Human Papillomavirus Immunization Programs on Rates of Anogenital Warts in British Columbia, Canada, 2000 to 2017
BACKGROUND: In 2008, British Columbia (BC) implemented a school-based quadrivalent human papillomavirus (HPV-4) immunization program for girls born in 1994 or later. In 2015, an expanded clinic-based program included men… BACKGROUND: In 2008, British Columbia (BC) implemented a school-based quadrivalent human papillomavirus (HPV-4) immunization program for girls born in 1994 or later. In 2015, an expanded clinic-based program included men…
View at publisherVoir chez l'éditeur - Implementing a province-wide mandatory vaccinate-or-mask policy at healthcare facilities in British Columbia, Canada Implementing a province-wide mandatory vaccinate-or-mask policy at healthcare facilities in British Columbia, Canada
- Incorporation of health economic evaluation into immunization policy-making in Canada: Barriers and facilitators Incorporation of health economic evaluation into immunization policy-making in Canada: Barriers and facilitators
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Indigenous Peoples, settler colonialism, and access to health care in rural and northern Ontario
Indigenous Peoples, settler colonialism, and access to health care in rural and northern Ontario
In Canada rural and northern communities, particularly Indigenous communities, face challenges disproportionate to their urban counterparts in accessing health care services. Existing health research on rural communities has tended to… In Canada rural and northern communities, particularly Indigenous communities, face challenges disproportionate to their urban counterparts in accessing health care services. Existing health research on rural communities has tended to…
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Indirect impact of childhood 13-valent pneumococcal conjugate vaccine (PCV13) in Canadian older adults: a Canadian Immunization Research Network (CIRN) retrospective observational study
Indirect impact of childhood 13-valent pneumococcal conjugate vaccine (PCV13) in Canadian older adults: a Canadian Immunization Research Network (CIRN) retrospective observational study
BACKGROUND: 13-valent pneumococcal conjugate vaccine (PCV13) has been part of publicly funded childhood immunisation programmes in Ontario and British Columbia (BC) since 2010. We assessed the indirect impact of infant… BACKGROUND: 13-valent pneumococcal conjugate vaccine (PCV13) has been part of publicly funded childhood immunisation programmes in Ontario and British Columbia (BC) since 2010. We assessed the indirect impact of infant…
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Influence of Obesity on Pneumococcus Infection Risk in the Elderly
Influence of Obesity on Pneumococcus Infection Risk in the Elderly
Obesity negatively affects immune function and host defense mechanisms. Obesity is associated with chronic activation of the innate immune system and consequent local and systemic inflammation which contribute to pathologic… Obesity negatively affects immune function and host defense mechanisms. Obesity is associated with chronic activation of the innate immune system and consequent local and systemic inflammation which contribute to pathologic…
View at publisherVoir chez l'éditeur - Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network) Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network)
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Intersecting Inequities in COVID-19 Vaccination: A Discourse Analysis of Information Use and Decision-Making Among Ethnically Diverse Parents in Canada
Intersecting Inequities in COVID-19 Vaccination: A Discourse Analysis of Information Use and Decision-Making Among Ethnically Diverse Parents in Canada
BACKGROUND: Little is known about how intersecting social privilege and disadvantage contribute to inequities in COVID-19 information use and vaccine access. This study explored how social inequities intersect to shape… BACKGROUND: Little is known about how intersecting social privilege and disadvantage contribute to inequities in COVID-19 information use and vaccine access. This study explored how social inequities intersect to shape…
View at publisherVoir chez l'éditeur - Investigating attributes of stigma towards individuals who did not receive a COVID-19 vaccine: An analysis of user comment threads on Reddit conducted by the Canadian Immunization Research Network (CIRN) Investigating attributes of stigma towards individuals who did not receive a COVID-19 vaccine: An analysis of user comment threads on Reddit conducted by the Canadian Immunization Research Network (CIRN)
- Knowledge, attitudes, beliefs, and behaviors of university students, faculty, and staff during a meningococcal serogroup B outbreak vaccination program Knowledge, attitudes, beliefs, and behaviors of university students, faculty, and staff during a meningococcal serogroup B outbreak vaccination program
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Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
Background: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50… Background: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50…
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Limited durability of protection conferred by XBB.1.5 vaccines against omicron-associated severe outcomes among community-dwelling adults, Ontario, Canada
Limited durability of protection conferred by XBB.1.5 vaccines against omicron-associated severe outcomes among community-dwelling adults, Ontario, Canada
We estimated XBB.1.5 vaccine effectiveness (VE) against hospitalization/death among adults aged ≥50 years in Ontario, Canada, from September 2023 to June 2024. Compared with non-XBB.1.5 vaccinees, the initial protection at… We estimated XBB.1.5 vaccine effectiveness (VE) against hospitalization/death among adults aged ≥50 years in Ontario, Canada, from September 2023 to June 2024. Compared with non-XBB.1.5 vaccinees, the initial protection at…
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Long-term impact of the COVID-19 pandemic on childhood vaccination coverage in Quebec, Canada: A cohort study from the Canadian immunization research network
Long-term impact of the COVID-19 pandemic on childhood vaccination coverage in Quebec, Canada: A cohort study from the Canadian immunization research network
Objective: The COVID-19 pandemic disrupted routine childhood vaccination globally, increasing the risk of resurgences of vaccine-preventable diseases. This study assessed the long-term impact of the pandemic on vaccination coverage and… Objective: The COVID-19 pandemic disrupted routine childhood vaccination globally, increasing the risk of resurgences of vaccine-preventable diseases. This study assessed the long-term impact of the pandemic on vaccination coverage and…
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Mailed Audit and Feedback for Antibiotic Prescribing in Primary Care
Mailed Audit and Feedback for Antibiotic Prescribing in Primary Care
Importance: Inappropriate antimicrobial use is a major but modifiable contributor to antimicrobial costs and harms. To address this global threat, many countries have implemented national stewardship programs. However, the cost-effectiveness… Importance: Inappropriate antimicrobial use is a major but modifiable contributor to antimicrobial costs and harms. To address this global threat, many countries have implemented national stewardship programs. However, the cost-effectiveness…
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Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study
Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study
OBJECTIVE: To estimate the effectiveness of maternal mRNA covid-19 vaccination during pregnancy against delta and omicron severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and hospital admission in infants. DESIGN: Test… OBJECTIVE: To estimate the effectiveness of maternal mRNA covid-19 vaccination during pregnancy against delta and omicron severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and hospital admission in infants. DESIGN: Test…
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Measles seroprevalence among individuals serologically tested in Ontario, Canada
Measles seroprevalence among individuals serologically tested in Ontario, Canada
BACKGROUND: Canada eliminated measles in 1998, but the risk of outbreaks remains due to sub-optimal vaccine coverage and imported cases. To address limitations of vaccine coverage data, we measured measles… BACKGROUND: Canada eliminated measles in 1998, but the risk of outbreaks remains due to sub-optimal vaccine coverage and imported cases. To address limitations of vaccine coverage data, we measured measles…
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Measles Serosurveys: A Solution in Search of the Right Problem
Measles Serosurveys: A Solution in Search of the Right Problem
OPINION article Front. Public Health, 15 July 2021Sec. Infectious Diseases – Surveillance, Prevention and Treatment https://doi.org/10.3389/fpubh.2021.539325 OPINION article Front. Public Health, 15 July 2021Sec. Infectious Diseases – Surveillance, Prevention and Treatment https://doi.org/10.3389/fpubh.2021.539325
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Measuring the long-term impact of the COVID-19 pandemic on HPV vaccination in Quebec, Canada: A cohort study from the Canadian immunization research network
Measuring the long-term impact of the COVID-19 pandemic on HPV vaccination in Quebec, Canada: A cohort study from the Canadian immunization research network
OBJECTIVES: School-based vaccine programs in Quebec experienced significant disruptions due to the COVID-19 pandemic. Some vaccines offered in schools, such as the human papillomavirus (HPV) vaccine, continue to fall short… OBJECTIVES: School-based vaccine programs in Quebec experienced significant disruptions due to the COVID-19 pandemic. Some vaccines offered in schools, such as the human papillomavirus (HPV) vaccine, continue to fall short…
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Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19
Measuring waning protection from seasonal influenza vaccination during nine influenza seasons, Ontario, Canada, 2010/11 to 2018/19
Background Waning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals are subject to… Background Waning immunity from seasonal influenza vaccination can cause suboptimal protection during peak influenza activity. However, vaccine effectiveness studies assessing waning immunity using vaccinated and unvaccinated individuals are subject to…
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Modestly protective cytomegalovirus vaccination of young children effectively prevents congenital infection at the population level
Modestly protective cytomegalovirus vaccination of young children effectively prevents congenital infection at the population level
A vaccine to prevent congenital cytomegalovirus infection (cCMV) is a public health priority. cCMV results from maternal primary or non-primary CMV infection (reinfection or reactivation of chronic infection) during pregnancy.… A vaccine to prevent congenital cytomegalovirus infection (cCMV) is a public health priority. cCMV results from maternal primary or non-primary CMV infection (reinfection or reactivation of chronic infection) during pregnancy.…
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Motivational interviewing: A powerful tool to address vaccine hesitancy
Motivational interviewing: A powerful tool to address vaccine hesitancy
According to the World Health Organization, vaccine hesitancy is among the top threats to global health and few effective strategies address this growing problem. In Canada, approximatively 20% of parents/caregivers… According to the World Health Organization, vaccine hesitancy is among the top threats to global health and few effective strategies address this growing problem. In Canada, approximatively 20% of parents/caregivers…
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mRNA COVID-19 vaccine safety among children and adolescents: a Canadian National Vaccine Safety Network cohort study
mRNA COVID-19 vaccine safety among children and adolescents: a Canadian National Vaccine Safety Network cohort study
Background: The Canadian National Vaccine Safety Network conducted active safety surveillance for COVID-19 vaccines. This study aimed to characterize the short-to-medium term safety of mRNA COVID-19 vaccines across the pediatric… Background: The Canadian National Vaccine Safety Network conducted active safety surveillance for COVID-19 vaccines. This study aimed to characterize the short-to-medium term safety of mRNA COVID-19 vaccines across the pediatric…
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Naturally acquired antibody against Haemophilus influenzae type a in pediatric saliva
Naturally acquired antibody against Haemophilus influenzae type a in pediatric saliva
We developed a salivary assay for the detection of naturally acquired IgA antibody against Haemophilus influenzae type a (Hia) capsular polysaccharide in healthy Indigenous children from Northwestern Ontario, Canada. Hia-specific… We developed a salivary assay for the detection of naturally acquired IgA antibody against Haemophilus influenzae type a (Hia) capsular polysaccharide in healthy Indigenous children from Northwestern Ontario, Canada. Hia-specific…
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Non-inferior antibody levels for HPV16/18 after extended two-dose schedules compared with a six-month interval: findings of a systematic review and meta-analysis
Non-inferior antibody levels for HPV16/18 after extended two-dose schedules compared with a six-month interval: findings of a systematic review and meta-analysis
Protection after human papillomavirus (HPV) vaccination can be maximized by optimizing vaccination schedules. We systematically reviewed immunogenicity and effectiveness of HPV vaccines administered 6 months apart compared with longer intervals.… Protection after human papillomavirus (HPV) vaccination can be maximized by optimizing vaccination schedules. We systematically reviewed immunogenicity and effectiveness of HPV vaccines administered 6 months apart compared with longer intervals.…
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Observed versus expected rates of myocarditis after SARS-CoV-2 vaccination: a population-based cohort study
Observed versus expected rates of myocarditis after SARS-CoV-2 vaccination: a population-based cohort study
BACKGROUND: Postmarketing evaluations have linked myocarditis to SARS-CoV-2 mRNA vaccines. We sought to estimate the incidence of myocarditis after mRNA vaccination against SARS-CoV-2, and to compare the incidence with expected… BACKGROUND: Postmarketing evaluations have linked myocarditis to SARS-CoV-2 mRNA vaccines. We sought to estimate the incidence of myocarditis after mRNA vaccination against SARS-CoV-2, and to compare the incidence with expected…
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Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19
Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19
Background: We report characteristics and outcomes of adults admitted to Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) Network hospitals with COVID-19 in 2020. Methods: Patients with laboratory-confirmed COVID-19… Background: We report characteristics and outcomes of adults admitted to Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) Network hospitals with COVID-19 in 2020. Methods: Patients with laboratory-confirmed COVID-19…
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Optimizing communication material to address vaccine hesitancy
Optimizing communication material to address vaccine hesitancy
Vaccine hesitancy (the reluctance to accept recommended vaccines) is a complex issue that poses risk communication challenges for public health authorities and clinicians. Studies have shown that providing too much… Vaccine hesitancy (the reluctance to accept recommended vaccines) is a complex issue that poses risk communication challenges for public health authorities and clinicians. Studies have shown that providing too much…
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Palivizumab’s real-world effectiveness: a population-based study in Ontario, Canada, 1993–2017
Palivizumab’s real-world effectiveness: a population-based study in Ontario, Canada, 1993–2017
OBJECTIVE: To evaluate the effectiveness of two palivizumab programmes targeting high-risk infants, defined by prematurity, diagnosis of comorbidities and geography, and assess potential disparities by neighbourhood income. DESIGN: Controlled, interrupted… OBJECTIVE: To evaluate the effectiveness of two palivizumab programmes targeting high-risk infants, defined by prematurity, diagnosis of comorbidities and geography, and assess potential disparities by neighbourhood income. DESIGN: Controlled, interrupted…
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Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada
Parental acceptability of new RSV preventive therapies for infants: A cross-sectional survey in Canada
Two new RSV immunization products exist for infants: a prenatal vaccine (RSVpreF) and a long-acting monoclonal antibody for infants (nirsevimab). While both showed promise in clinical trials, implementation has varied… Two new RSV immunization products exist for infants: a prenatal vaccine (RSVpreF) and a long-acting monoclonal antibody for infants (nirsevimab). While both showed promise in clinical trials, implementation has varied…
View at publisherVoir chez l'éditeur - PCR-based discrimination of emerging Streptococcus pneumoniae serotypes 22F and 33F PCR-based discrimination of emerging Streptococcus pneumoniae serotypes 22F and 33F
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Perceptions of COVID-19 vaccination and factors influencing COVID-19 vaccine acceptance among indigenous peoples in Quebec, Canada: Insights from a facebook posts and comments analysis
Perceptions of COVID-19 vaccination and factors influencing COVID-19 vaccine acceptance among indigenous peoples in Quebec, Canada: Insights from a facebook posts and comments analysis
Vaccination rates in Canada tend to be lower among Indigenous peoples than the rest of the population. The COVID-19 pandemic provided an unprecedented opportunity to better understand Indigenous perceptions about… Vaccination rates in Canada tend to be lower among Indigenous peoples than the rest of the population. The COVID-19 pandemic provided an unprecedented opportunity to better understand Indigenous perceptions about…
View at publisherVoir chez l'éditeur - Pharmacists as immunizers to Improve coverage and provider/recipient satisfaction: A prospective, C ontrolled C ommunity E mbedded S tudy with vaccine S with low coverage rates (the Improve ACCESS Study): Study summary and anticipated significance Pharmacists as immunizers to Improve coverage and provider/recipient satisfaction: A prospective, C ontrolled C ommunity E mbedded S tudy with vaccine S with low coverage rates (the Improve ACCESS Study): Study summary and anticipated significance
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Pharmacological treatment for patients with coronavirus disease 2019: systematic review of randomized controlled trials
Pharmacological treatment for patients with coronavirus disease 2019: systematic review of randomized controlled trials
Background : The best treatment for COVID-19 is not known, with numerous agents under investigation. We determined the outcomes of patients with COVID-19 treated with different pharmacological agents. Methods :… Background : The best treatment for COVID-19 is not known, with numerous agents under investigation. We determined the outcomes of patients with COVID-19 treated with different pharmacological agents. Methods :…
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Physician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network
Physician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network
BACKGROUND AND OBJECTIVES: Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination among physicians… BACKGROUND AND OBJECTIVES: Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination among physicians…
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Population immunity to varicella in Canada: A Canadian Immunization Research Network (CIRN) study
Population immunity to varicella in Canada: A Canadian Immunization Research Network (CIRN) study
INTRODUCTION: The incidence of varicella in Canada has decreased by almost 99% since vaccination was introduced. However, variation in the timing and eligibility of vaccination programs across the country has… INTRODUCTION: The incidence of varicella in Canada has decreased by almost 99% since vaccination was introduced. However, variation in the timing and eligibility of vaccination programs across the country has…
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Population-based incidence of invasive pneumococcal disease in children and adults in Ontario and British Columbia, 2002–2018: A Canadian Immunization Research Network (CIRN) study
Population-based incidence of invasive pneumococcal disease in children and adults in Ontario and British Columbia, 2002–2018: A Canadian Immunization Research Network (CIRN) study
BACKGROUND: Invasive pneumococcal disease (IPD) burden, evaluated in Canada using reported confirmed cases in surveillance systems, is likely underestimated due to underreporting. We estimated the burden of IPD in Ontario… BACKGROUND: Invasive pneumococcal disease (IPD) burden, evaluated in Canada using reported confirmed cases in surveillance systems, is likely underestimated due to underreporting. We estimated the burden of IPD in Ontario…
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Prebunking messaging to inoculate against COVID-19 vaccine misinformation: an effective strategy for public health
Prebunking messaging to inoculate against COVID-19 vaccine misinformation: an effective strategy for public health
Background Vaccination coverage needs to reach more than 80% to resolve the COVID-19 pandemic, but vaccine hesitancy, fuelled by misinformation, may jeopardize this goal. Unvaccinated older adults are not only… Background Vaccination coverage needs to reach more than 80% to resolve the COVID-19 pandemic, but vaccine hesitancy, fuelled by misinformation, may jeopardize this goal. Unvaccinated older adults are not only…
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Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale
Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale
We developed and validated the Influenza Severity Scale (ISS), a standardized risk assessment for influenza, to estimate and predict the probability of major clinical events in patients with laboratory-confirmed infection.… We developed and validated the Influenza Severity Scale (ISS), a standardized risk assessment for influenza, to estimate and predict the probability of major clinical events in patients with laboratory-confirmed infection.…
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Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study
Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease in the North American Arctic and Sub-Arctic regions, mainly affecting young Indigenous children. In this… Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease in the North American Arctic and Sub-Arctic regions, mainly affecting young Indigenous children. In this…
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Prevalence of Oral Human Papillomavirus Infection Among Urban Gay, Bisexual, and Other Men Who Have Sex With Men in Canada, 2017–2019
Prevalence of Oral Human Papillomavirus Infection Among Urban Gay, Bisexual, and Other Men Who Have Sex With Men in Canada, 2017–2019
BACKGROUND: Oral human papillomavirus (HPV) infections are a leading cause of oropharyngeal cancers. In 2015 and 2016, HPV vaccines became publicly funded for gay, bisexual, and other men who have… BACKGROUND: Oral human papillomavirus (HPV) infections are a leading cause of oropharyngeal cancers. In 2015 and 2016, HPV vaccines became publicly funded for gay, bisexual, and other men who have…
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Protection Conferred by COVID-19 Vaccination, Prior SARS-CoV-2 Infection, or Hybrid Immunity Against Omicron-Associated Severe Outcomes Among Community-Dwelling Adults
Protection Conferred by COVID-19 Vaccination, Prior SARS-CoV-2 Infection, or Hybrid Immunity Against Omicron-Associated Severe Outcomes Among Community-Dwelling Adults
INTRODUCTION: We assessed protection from coronavirus disease 2019 (COVID-19) vaccines and/or prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection against Omicron-associated severe outcomes during successive sublineage-predominant periods. METHODS: We… INTRODUCTION: We assessed protection from coronavirus disease 2019 (COVID-19) vaccines and/or prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection against Omicron-associated severe outcomes during successive sublineage-predominant periods. METHODS: We…
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Public awareness, attitudes, beliefs, and behaviors regarding the role of pharmacists as immunizers
Public awareness, attitudes, beliefs, and behaviors regarding the role of pharmacists as immunizers
Vaccine coverage is below desired levels in Canada, despite National Advisory Committee on Immunization recommendations. One solution to improve coverage is to offer vaccines in pharmacies. We explore the awareness,… Vaccine coverage is below desired levels in Canada, despite National Advisory Committee on Immunization recommendations. One solution to improve coverage is to offer vaccines in pharmacies. We explore the awareness,…
View at publisherVoir chez l'éditeur - Rapid surveillance for health events following a mass meningococcal B vaccine program in a university setting: A Canadian Immunization Research Network study Rapid surveillance for health events following a mass meningococcal B vaccine program in a university setting: A Canadian Immunization Research Network study
- Real-world effectiveness of nirsevimab against respiratory syncytial virus disease in infants: a systematic review and meta-analysis Real-world effectiveness of nirsevimab against respiratory syncytial virus disease in infants: a systematic review and meta-analysis
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Relatedness of the incidence decay with exponential adjustment (IDEA) model, “Farr's law” and SIR compartmental difference equation models
Relatedness of the incidence decay with exponential adjustment (IDEA) model, “Farr's law” and SIR compartmental difference equation models
Mathematical models are often regarded as recent innovations in the description and analysis of infectious disease outbreaks and epidemics, but simple mathematical expressions have been in use for projection of… Mathematical models are often regarded as recent innovations in the description and analysis of infectious disease outbreaks and epidemics, but simple mathematical expressions have been in use for projection of…
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Relationship Between Frailty and Respiratory Syncytial Virus Infection in Hospitalized Older Adults
Relationship Between Frailty and Respiratory Syncytial Virus Infection in Hospitalized Older Adults
Background This study aimed to evaluate the impact of frailty on clinical outcomes and disease severity of respiratory syncytial virus (RSV) infection in older adults using data from the CIRN… Background This study aimed to evaluate the impact of frailty on clinical outcomes and disease severity of respiratory syncytial virus (RSV) infection in older adults using data from the CIRN…
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Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network
Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network
BACKGROUND: Consideration of cost determinants is crucial to inform delivery of public vaccination programs. OBJECTIVES: To estimate the average total cost of laboratory-confirmed influenza requiring hospitalization in Canadians prior to,… BACKGROUND: Consideration of cost determinants is crucial to inform delivery of public vaccination programs. OBJECTIVES: To estimate the average total cost of laboratory-confirmed influenza requiring hospitalization in Canadians prior to,…
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Resources available for parent-provider vaccine communication in pregnancy in Canada: a scoping review
Resources available for parent-provider vaccine communication in pregnancy in Canada: a scoping review
OBJECTIVE: Vaccination in pregnancy (VIP) is a protective measure for pregnant individuals and their babies. Healthcare provider’s (HCP) recommendations are important in promoting VIP. However, a lack of strong recommendations… OBJECTIVE: Vaccination in pregnancy (VIP) is a protective measure for pregnant individuals and their babies. Healthcare provider’s (HCP) recommendations are important in promoting VIP. However, a lack of strong recommendations…
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Risk and intersectional power relations: an exploration of the implications of early COVID-19 pandemic responses for pregnant women
Risk and intersectional power relations: an exploration of the implications of early COVID-19 pandemic responses for pregnant women
The World Health Organization and many national health authorities identifie pregnant women as requiring extra protections during the COVID-19 global pandemic. Nevertheless, many initial responses to the COVID-19 pandemic were… The World Health Organization and many national health authorities identifie pregnant women as requiring extra protections during the COVID-19 global pandemic. Nevertheless, many initial responses to the COVID-19 pandemic were…
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Safety and immunogenicity of a delayed booster dose of the rVSVΔG-ZEBOV-GP vaccine for prevention of Ebola virus disease: a multicentre, open-label, phase 2 randomised controlled trial
Safety and immunogenicity of a delayed booster dose of the rVSVΔG-ZEBOV-GP vaccine for prevention of Ebola virus disease: a multicentre, open-label, phase 2 randomised controlled trial
BACKGROUND: rVSVΔG-ZEBOV-GP is the first approved vaccine with clinical efficacy against Ebola virus disease. Although a seroprotective threshold has not been defined for those at occupational risk of exposure, the… BACKGROUND: rVSVΔG-ZEBOV-GP is the first approved vaccine with clinical efficacy against Ebola virus disease. Although a seroprotective threshold has not been defined for those at occupational risk of exposure, the…
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Safety of co-administration of COVID-19 and seasonal influenza vaccines in individuals with autoimmune diseases from the Canadian National Vaccine Safety Network
Safety of co-administration of COVID-19 and seasonal influenza vaccines in individuals with autoimmune diseases from the Canadian National Vaccine Safety Network
The Canadian National Vaccine Safety Network conducted active safety surveillance for adverse events following COVID-19 and influenza immunizations. This analysis evaluated the association between the administration of mRNA COVID-19 vaccines,… The Canadian National Vaccine Safety Network conducted active safety surveillance for adverse events following COVID-19 and influenza immunizations. This analysis evaluated the association between the administration of mRNA COVID-19 vaccines,…
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Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network
Safety of COVID-19 and influenza vaccines in children and adolescents with immunocompromised or autoimmune conditions: Findings from the Canadian National Vaccine Safety (CANVAS) network
Safety data on COVID-19 and influenza vaccination in immunocompromised and/or autoimmune pediatric populations remains limited. This study evaluated post-vaccination health events in this vulnerable population using active surveillance data from… Safety data on COVID-19 and influenza vaccination in immunocompromised and/or autoimmune pediatric populations remains limited. This study evaluated post-vaccination health events in this vulnerable population using active surveillance data from…
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Safety of COVID-19 vaccines among pregnant individuals in Quebec, Canada: a population-based retrospective cohort study from the Canadian Immunization Research Network
Safety of COVID-19 vaccines among pregnant individuals in Quebec, Canada: a population-based retrospective cohort study from the Canadian Immunization Research Network
OBJECTIVE: To estimate the association between maternal COVID-19 vaccination during pregnancy and adverse neonatal and maternal outcomes. DESIGN: Population-based retrospective cohort study using a hospitalisation database linked with other health… OBJECTIVE: To estimate the association between maternal COVID-19 vaccination during pregnancy and adverse neonatal and maternal outcomes. DESIGN: Population-based retrospective cohort study using a hospitalisation database linked with other health…
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Safety of mRNA COVID-19 Vaccination during Pregnancy: Findings from Post-vaccination Follow-up Data from the Canadian National Vaccine Safety Network
Safety of mRNA COVID-19 Vaccination during Pregnancy: Findings from Post-vaccination Follow-up Data from the Canadian National Vaccine Safety Network
This communication reports post-vaccination follow-up findings from the Canadian National Vaccine Safety network on COVID-19 vaccination during pregnancy. Among 6606 pregnant individuals who received an mRNA COVID-19 primary series, 4302… This communication reports post-vaccination follow-up findings from the Canadian National Vaccine Safety network on COVID-19 vaccination during pregnancy. Among 6606 pregnant individuals who received an mRNA COVID-19 primary series, 4302…
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Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal
Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal
Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with… Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with…
View at publisherVoir chez l'éditeur - Seroprevalence of IgG and IgM antibodies to Haemophilus influenzae type a in Canadian children Seroprevalence of IgG and IgM antibodies to Haemophilus influenzae type a in Canadian children
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Seroprevalence of rubella antibodies and determinants of susceptibility to rubella in a cohort of pregnant women in Canada, 2008–2011
Seroprevalence of rubella antibodies and determinants of susceptibility to rubella in a cohort of pregnant women in Canada, 2008–2011
Long term control of rubella and congenital rubella syndrome relies on high population-level immunity against rubella, particularly among women of childbearing age. In Canada, all pregnant women should be screened… Long term control of rubella and congenital rubella syndrome relies on high population-level immunity against rubella, particularly among women of childbearing age. In Canada, all pregnant women should be screened…
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Serotype-specific pneumococcal conjugate vaccine effectiveness in Canadian children: an indirect cohort study using Bayesian hierarchical modeling of multisite data
Serotype-specific pneumococcal conjugate vaccine effectiveness in Canadian children: an indirect cohort study using Bayesian hierarchical modeling of multisite data
BACKGROUND: Pneumococcal conjugate vaccine (PCV) effectiveness (VE) against invasive pneumococcal disease (IPD) varies across Streptococcus pneumoniae serotypes (STs). Combining data from multiple sites helps obtain reliable serotype-specific VE estimates but… BACKGROUND: Pneumococcal conjugate vaccine (PCV) effectiveness (VE) against invasive pneumococcal disease (IPD) varies across Streptococcus pneumoniae serotypes (STs). Combining data from multiple sites helps obtain reliable serotype-specific VE estimates but…
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Sociodemographic correlates of human papillomavirus and hepatitis B vaccination status in Canada: a cross-sectional study
Sociodemographic correlates of human papillomavirus and hepatitis B vaccination status in Canada: a cross-sectional study
Introduction: Human papillomavirus (HPV) and hepatitis B (HBV) vaccines are critical to cancer prevention strategies; however, achieving high vaccination coverage remains a challenge. We aimed to investigate the proportion of… Introduction: Human papillomavirus (HPV) and hepatitis B (HBV) vaccines are critical to cancer prevention strategies; however, achieving high vaccination coverage remains a challenge. We aimed to investigate the proportion of…
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Strategies to Prevent Early and Late-Onset Group B Streptococcal Infection via Interventions in Pregnancy
Strategies to Prevent Early and Late-Onset Group B Streptococcal Infection via Interventions in Pregnancy
is a Gram-positive bacterium that typically colonizes 10-30% of pregnant women, causing chorioamnionitis, preterm birth, and stillbirth, as well as neonatal sepsis and meningitis with early-onset disease (EOD) or late-onset… is a Gram-positive bacterium that typically colonizes 10-30% of pregnant women, causing chorioamnionitis, preterm birth, and stillbirth, as well as neonatal sepsis and meningitis with early-onset disease (EOD) or late-onset…
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Streptococcus pneumoniae serotype 3 is masking PCV13-mediated herd immunity in Canadian adults hospitalized with community acquired pneumonia: A study from the Serious Outcomes Surveillance (SOS) Network of the Canadian immunization research Network (CIRN)
Streptococcus pneumoniae serotype 3 is masking PCV13-mediated herd immunity in Canadian adults hospitalized with community acquired pneumonia: A study from the Serious Outcomes Surveillance (SOS) Network of the Canadian immunization research Network (CIRN)
BACKGROUND: and IPD from 2010 to 2015. METHODS: . RESULTS: and IPD cases, but remained unchanged over the study years. CONCLUSION: , and represent between 5 and 10% of all… BACKGROUND: and IPD from 2010 to 2015. METHODS: . RESULTS: and IPD cases, but remained unchanged over the study years. CONCLUSION: , and represent between 5 and 10% of all…
View at publisherVoir chez l'éditeur - Supporting informed decision-making about vaccination: an analysis of two official websites Supporting informed decision-making about vaccination: an analysis of two official websites
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Switching from a 2-dose to a 1-dose program of gender-neutral routine vaccination against human papillomavirus in Canada: a mathematical modelling analysis
Switching from a 2-dose to a 1-dose program of gender-neutral routine vaccination against human papillomavirus in Canada: a mathematical modelling analysis
BACKGROUND: Worldwide, countries are examining whether to implement 1-dose human papillomavirus (HPV) vaccination instead of using 2 doses. To inform policy, we sought to project the population-level impact and efficiency… BACKGROUND: Worldwide, countries are examining whether to implement 1-dose human papillomavirus (HPV) vaccination instead of using 2 doses. To inform policy, we sought to project the population-level impact and efficiency…
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The barriers, facilitators and association of vaccine certificates on COVID-19 vaccine uptake: a scoping review
The barriers, facilitators and association of vaccine certificates on COVID-19 vaccine uptake: a scoping review
BACKGROUND: Globally, COVID-19 vaccines have proven to be instrumental for promoting population health by reducing illness from SARS-CoV-2. Vaccine certificates emerged as a potentially promising solution for encouraging vaccination and… BACKGROUND: Globally, COVID-19 vaccines have proven to be instrumental for promoting population health by reducing illness from SARS-CoV-2. Vaccine certificates emerged as a potentially promising solution for encouraging vaccination and…
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The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer
The contributions of T cell-mediated immunity to protection from vaccine-preventable diseases: A primer
In the face of the ever-present burden of emerging and reemerging infectious diseases, there is a growing need to comprehensively assess individual- and population-level immunity to vaccine-preventable diseases (VPDs). Many… In the face of the ever-present burden of emerging and reemerging infectious diseases, there is a growing need to comprehensively assess individual- and population-level immunity to vaccine-preventable diseases (VPDs). Many…
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The Efficacy of a Brief, Altruism-Eliciting Video Intervention in Enhancing COVID-19 Vaccination Intentions Among a Population-Based Sample of Younger Adults: Randomized Controlled Trial
The Efficacy of a Brief, Altruism-Eliciting Video Intervention in Enhancing COVID-19 Vaccination Intentions Among a Population-Based Sample of Younger Adults: Randomized Controlled Trial
BACKGROUND: High COVID-19 vaccine uptake is crucial to containing the pandemic and reducing hospitalizations and deaths. Younger adults (aged 20-39 years) have demonstrated lower levels of vaccine uptake compared to… BACKGROUND: High COVID-19 vaccine uptake is crucial to containing the pandemic and reducing hospitalizations and deaths. Younger adults (aged 20-39 years) have demonstrated lower levels of vaccine uptake compared to…
View at publisherVoir chez l'éditeur - The Global Impact of Vaccine Certificates on COVID-19 Vaccine Uptake: A Scoping Review The Global Impact of Vaccine Certificates on COVID-19 Vaccine Uptake: A Scoping Review
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The good, the bad, and the ugly: A qualitative evaluation of web-based COVID-19 vaccine communication in Canada
The good, the bad, and the ugly: A qualitative evaluation of web-based COVID-19 vaccine communication in Canada
Poor website accessibility and usability with credible website/information sources can create barriers to the equitable uptake of vaccines. Scarce research investigates how intended users interact with and perceive official COVID-19… Poor website accessibility and usability with credible website/information sources can create barriers to the equitable uptake of vaccines. Scarce research investigates how intended users interact with and perceive official COVID-19…
View at publisherVoir chez l'éditeur - The health and economic burden of pertussis in Canada: A microsimulation study The health and economic burden of pertussis in Canada: A microsimulation study
- The immune response to a two-dose schedule of quadrivalent HPV vaccine in 9–13 year-old girls: Is it influenced by age, menarche status or body mass index? The immune response to a two-dose schedule of quadrivalent HPV vaccine in 9–13 year-old girls: Is it influenced by age, menarche status or body mass index?
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The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada
The impact of repeated vaccination using 10-year vaccination history on protection against influenza in older adults: a test-negative design study across the 2010/11 to 2015/16 influenza seasons in Ontario, Canada
IntroductionAnnual influenza vaccination is recommended for older adults, but evidence regarding the impact of repeated vaccination has been inconclusive.AimWe investigated vaccine effectiveness (VE) against laboratory-confirmed influenza and the impact of… IntroductionAnnual influenza vaccination is recommended for older adults, but evidence regarding the impact of repeated vaccination has been inconclusive.AimWe investigated vaccine effectiveness (VE) against laboratory-confirmed influenza and the impact of…
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The impact of testing positive versus negative for COVID-19 on health-related quality of life: cross-sectional evidence from the Alberta post-COVID-19 follow-up survey
The impact of testing positive versus negative for COVID-19 on health-related quality of life: cross-sectional evidence from the Alberta post-COVID-19 follow-up survey
PURPOSE: The novel Coronavirus Disease 2019 (COVID-19) can have lasting physical and psychological outcomes, though little is known about the long-term impact of COVID-19 on the health-related quality of life… PURPOSE: The novel Coronavirus Disease 2019 (COVID-19) can have lasting physical and psychological outcomes, though little is known about the long-term impact of COVID-19 on the health-related quality of life…
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The impact of two-year community-wide pharmacy interventions on the public’s knowledge, attitudes, beliefs and behaviors about pharmacists as immunizers
The impact of two-year community-wide pharmacy interventions on the public’s knowledge, attitudes, beliefs and behaviors about pharmacists as immunizers
BACKGROUND: Immunization rates for vaccine-preventable diseases remain well below targets worldwide, leading to unnecessary morbidity and mortality, and heavy economic burdens to healthcare systems and workforces. One promising avenue to… BACKGROUND: Immunization rates for vaccine-preventable diseases remain well below targets worldwide, leading to unnecessary morbidity and mortality, and heavy economic burdens to healthcare systems and workforces. One promising avenue to…
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The Problem with Delaying Measles Elimination
The Problem with Delaying Measles Elimination
Measles is a highly infectious disease leading to high morbidity and mortality impacting people’s lives and economies across the globe. The measles vaccine saves more lives than any other vaccine… Measles is a highly infectious disease leading to high morbidity and mortality impacting people’s lives and economies across the globe. The measles vaccine saves more lives than any other vaccine…
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The safety of seasonal influenza vaccination among patients prescribed immune checkpoint inhibitors: A self-controlled case series study using administrative data.
The safety of seasonal influenza vaccination among patients prescribed immune checkpoint inhibitors: A self-controlled case series study using administrative data.
6606 Background: Immune checkpoint inhibitor (ICI) therapy for cancer patients carries a risk of severe immune-related adverse events (IRAEs). Since vaccines are immunomodulatory, administering seasonal influenza vaccinations to individuals on… 6606 Background: Immune checkpoint inhibitor (ICI) therapy for cancer patients carries a risk of severe immune-related adverse events (IRAEs). Since vaccines are immunomodulatory, administering seasonal influenza vaccinations to individuals on…
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Time trends in social contacts before and during the COVID-19 pandemic: the CONNECT study
Time trends in social contacts before and during the COVID-19 pandemic: the CONNECT study
BACKGROUND: Since the beginning of the COVID-19 pandemic, many countries, including Canada, have adopted unprecedented physical distancing measures such as closure of schools and non-essential businesses, and restrictions on gatherings… BACKGROUND: Since the beginning of the COVID-19 pandemic, many countries, including Canada, have adopted unprecedented physical distancing measures such as closure of schools and non-essential businesses, and restrictions on gatherings…
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Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic
Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic
BACKGROUND: As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals… BACKGROUND: As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals…
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Treatment of UTIs in Infants <2 Months: A Living Systematic Review
Treatment of UTIs in Infants <2 Months: A Living Systematic Review
CONTEXT Urinary tract infections (UTIs) are the most common bacterial infections in infants <2 months of age. However, there are no clear guidelines on the appropriate duration of antibiotics in… CONTEXT Urinary tract infections (UTIs) are the most common bacterial infections in infants <2 months of age. However, there are no clear guidelines on the appropriate duration of antibiotics in…
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Understanding Vaccine Hesitancy in Canada: Results of a Consultation Study by the Canadian Immunization Research Network
Understanding Vaccine Hesitancy in Canada: Results of a Consultation Study by the Canadian Immunization Research Network
“Vaccine hesitancy” is a concept now frequently used in vaccination discourse. The increased popularity of this concept in both academic and public health circles is challenging previously held perspectives that… “Vaccine hesitancy” is a concept now frequently used in vaccination discourse. The increased popularity of this concept in both academic and public health circles is challenging previously held perspectives that…
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Using Laboratory-Confirmed Outcomes to Study Pediatric Influenza and Influenza Vaccine Epidemiology in Ontario
Using Laboratory-Confirmed Outcomes to Study Pediatric Influenza and Influenza Vaccine Epidemiology in Ontario
Annual epidemics of seasonal influenza continue to cause substantial morbidity in young children. Influenza is among several respiratory viruses that cause illness in children, in addition to a large burden… Annual epidemics of seasonal influenza continue to cause substantial morbidity in young children. Influenza is among several respiratory viruses that cause illness in children, in addition to a large burden…
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Vaccination during pregnancy: Canadian maternity care providers' opinions and practices
Vaccination during pregnancy: Canadian maternity care providers' opinions and practices
A number of countries have implemented vaccination in pregnancy as a strategy to reduce the burden of influenza and pertussis. The aim of this study was to assess the involvement… A number of countries have implemented vaccination in pregnancy as a strategy to reduce the burden of influenza and pertussis. The aim of this study was to assess the involvement…
View at publisherVoir chez l'éditeur - Vaccine coverage among children with epilepsy in two Canadian provinces: A Canadian immunization research network study Vaccine coverage among children with epilepsy in two Canadian provinces: A Canadian immunization research network study
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Vaccine Effectiveness Against 12-Month Incident and Persistent Anal Human Papillomavirus Infection Among Gay, Bisexual, and Other Men Who Have Sex With Men
Vaccine Effectiveness Against 12-Month Incident and Persistent Anal Human Papillomavirus Infection Among Gay, Bisexual, and Other Men Who Have Sex With Men
BACKGROUND: Real-world evidence of human papillomavirus (HPV) vaccine effectiveness (VE) against longitudinal outcomes is lacking among gay, bisexual, and other men who have sex with men (GBM). We compared 12-month… BACKGROUND: Real-world evidence of human papillomavirus (HPV) vaccine effectiveness (VE) against longitudinal outcomes is lacking among gay, bisexual, and other men who have sex with men (GBM). We compared 12-month…
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Vaccine effectiveness against laboratory-confirmed influenza hospitalizations among young children during the 2010-11 to 2013-14 influenza seasons in Ontario, Canada
Vaccine effectiveness against laboratory-confirmed influenza hospitalizations among young children during the 2010-11 to 2013-14 influenza seasons in Ontario, Canada
Uncertainty remains regarding the magnitude of effectiveness of influenza vaccines for preventing serious outcomes, especially among young children. We estimated vaccine effectiveness (VE) against laboratory-confirmed influenza hospitalizations among children aged… Uncertainty remains regarding the magnitude of effectiveness of influenza vaccines for preventing serious outcomes, especially among young children. We estimated vaccine effectiveness (VE) against laboratory-confirmed influenza hospitalizations among children aged…
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