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Rouleau I, De Serres G, Drolet JP, Banerjee D, Lemire C, Moore A, Paradis L, Alizadhefar R, Des Roches A, Chan ES, Stark D, Benoit M, Skowronski
DM. Allergic symptoms after pandemic infl uenza vaccination rarely caused by vaccine-specifi c IgE. J Allerg Clin Immunol 2012 J Allergy Clin
Immunol. 2012 Dec;130(6):1423-6.
Des Roches A, Paradis L, Gagnon R, Lemire C, Begin P, Carr S et al Egg-allergic patients can be safely vaccinated against infl uenza J Allergy Clin
Immunol. 2012 Nov;130(5):1213-1216.
Gaston De Serres, Marie-Claude Gariépy, Brenda Coleman, Isabelle Rouleau, Shelly McNeil, Mélanie Benoît, Allison McGeer, Ardith Ambrose, Judy
Needham, Chantal Bergeron, Cynthia Grenier, Kenna Sleigh, Arlene Kallos, Manale Ouakki, Najwa Ouhoummane, Grant Stiver, Louis Valiquette,
Anne McCarthy, Julie Bettinger, on behalf of the PHAC-CIHR infl uenza Research Network (PCIRN) Short and Long-Term Safety of the 2009 AS03-
Adjuvanted Pandemic Vaccine. Research Article | published 03 Jul 2012 | PLOS ONE 10.1371/journal.pone.0038563
RLN Reference Laboratory Network
Kuster SP, Coleman BL, Raboud J, McNeil S, De Serres G, Gubbay J, Hatchette T, Katz KC, Loeb M, Low D, Mazzulli T, Simor A, McGeer AJ, for
the Working Adult Infl uenza Cohort Study Group. Acute Care Hospital Workers and Risk of Infl uenza Infection during the 2009 H1N1 Infl uenza
Pandemic. 2013 Emerg Infect Dis (in press)
Karen K. Yam, Jyotsana Gupta, Elizabeth Allen, Brian Ward. Adjuvanted infl uenza vaccines in young and aged BALB/c mice. Poster. European
Congress of Immunology,Glasgow, Scotland, 5-8 September, 2012.
Katie Young , Manon Couture , Marc-André D’aoust , Nathalie Landry, Louis Vézina , and Brian Ward.. Innate and adaptive immune responses to
plant-based H5 VLP by murine splenocytes. Poster. European Congress of Immunology, Glasgow, Scotland, 5-8 September, 2012.
Katie Young, Manon Couture , Marc-André D’aoust , Nathalie Landry Louis Vézina, and Brian Ward . Innate and adaptive immune responses to
plant-based H5 VLP by murine splenocytes. Poster . Canadian Immunization Conference Dec 2-5, 2012.
Wisner, A. L. S., LeBlanc, J., Hatchette, T., El-Sherif, M., and McNeil, S. Molecular Detection of Streptococcus pneumoniae in Nasopharyngeal Swabs
and Deduction of Serotypes by PCR. 10th Canadian Immunization Conference, , Vancouver, BC, Canada, Dec 2-5, 2012.
Wisner, A. L. S., LeBlanc, J., Hatchette, T., El-Sherif, M., and McNeil, S for the PCIRN Serious Outcomes Surveillance Network Investigators.
Molecular Detection of Streptococcus pneumoniae in Nasopharyngeal Swabs and Deduction of Serotypes by Polymerase Chain Reaction (PCR).
Presentation. ID Research Day, Halifax, NS, Canada, April 23-24, 2012
Yam KK, Gupta J, Brewer A, Scheifele DW, Halperin S, Ward BJ, and PCIRN (Public Health Agency of Canada-Canadian Institute of Health
Research Infl uenza Research Network). 2012. Unusual patterns of IgG avidity in some young children following two doses of adjuvanted
pandemic H1N1(2009) infl uenza vaccine. Clin Vaccine Immunol 2013
Wisner, A. L. S., LeBlanc, J., Hatchette, T., El-Sherif, M., and McNeil, S. Molecular Detection of Streptococcus pneumoniae in Nasopharyngeal Swabs
and Deduction of Serotypes by PCR submitted abstract for AMMI CACMID Annual Conference, Quebec City, QC, Canada, April 4-6 2013,.
MacRae C, LeBlanc JJ, McNeil SA, Hatchette TF. Determination of the viral etiology and epidemiology of infl uenza-negative patients with acute
respiratory disease. (Dalhousie ID research day 2014; and IWK summer studentship 2013 – winner of best research project
Ward BJ, Hatchette TF and the other members of the PCIRN Reference Laboratories. Why is lab testing for infl uenza so diffi cult? PCIRN annual
meeting, Toronto. May 27, 2013 (oral presentation)
Lang A, LeBlanc J, Hatchette T, ElSherif M, McNeil S, on behalf of the PCIRN Serious Outcomes Surveillance Network investigators. Molecular
detection of streptococcus pneumonia in nasopharyngeal swabs and deduction of “sero”types by polymerase chain reaction (PCR). PCRIN annual
meeting, Toronto. May 27, 2013. (oral presentation)
Yam K. Long-term immune responses to AS03-adjuvanted, low antigen does infl uenza vaccine in BALB/c mice. PCIRN annual meeting, Toronto.
May 27, 2013. (oral presentation).
Yam KK, Gupta J, Brewer A, Scheifele DW, Halperin S, Ward BJ; Public Health Agency of Canada/Canadian Institute of Health Research, Infl uenza
Research Network (PCIRN) Rapid Trial Study 3 (RT-03) Investigators. Unusual patterns of IgG avidity in some young children following two doses
of the adjuvanted pandemic H1N1 (2009) infl uenza virus vaccine. Clin Vaccine Immunol. 2013 Apr;20(4):459-67
Pizzorno A, Abed Y, Bouhy X, Boivin G. Identifi cation of a permissive mutation restoring the fi tness of the H275Y Oseltamavir resistance mutation
in 2009 pandemic infl uenza A/H1N1 viruses. PCIRN annual meeting, Toronto. May 27, 2013. (poster)
Retamal M., Abed Y., Corbeil J. and Boivin G. Development of monoclonal antibodies against infl uenza A (H1N1)pdm09 surface proteins. PCIRN
annual meeting, Toronto. May 27, 2013. (poster)
Young K, Vézina L, Couture M, Arthus-Cartier G, Ward B. Plant-derived infl uenza H5-based virus-like particles preferentially associate with innate
phagocytic cells. PCIRN annual meeting, Toronto. May 27, 2013. (poster)
Young K, Couture M, D’Aoust MA, Landry N, Ward BJ. Generation and characterization of a plant-made infl uenza H5 virus-like particle containing
eGFP. (2014 submitted)
Yam K, Mallet C, Burt D, Ward BJ. Immune responses to extreme low-dose infl uenza antigen adjuvanted with AS03 in a BALB/c mouse model
(submitted 2014)
Retamal, M. Abed, Y., Corbeil, J., Boivin, G. Epitope mapping of the 2009 pandemic and the A/Brisbane/59/2007 seasonal (H1N1) infl uenza
virus haemagglutinins using mAbs and escape mutants. J Gen Virol. 2014 Nov;95(Pt 11):2377-89. doi: 10.1099/vir.0.067819-0. Epub 2014 Jul
30.
Retamal, M. et al. Heterosubtyic Protection Conferred by the Human Monoclonal Antibody PN-SIA28 Against Infl uenza A Lethal Infections in Mice.
Submitted to the journal Antimicrobial Agents and Chemotherapy.
Hatchette TF, Scholz H, Bolotin S, Crowcroft N, Jackson C, McLachlan E, Severini A; on behalf of the Immunity of Canadians and Risk of Epidemics
(iCARE) laboratory group and the Canadian Immunization Research Network (CIRN). Correlation Of The BioPlex Test and Plaque Reduction
Neutralization Test For Determining Antibody Immunity To Measles Virus. Poster presentation. Canadian Immunization Conference, 2014. Ottawa,
ON. Dec 3, 2014.
2015 ANNUAL REPORT 19
DM. Allergic symptoms after pandemic infl uenza vaccination rarely caused by vaccine-specifi c IgE. J Allerg Clin Immunol 2012 J Allergy Clin
Immunol. 2012 Dec;130(6):1423-6.
Des Roches A, Paradis L, Gagnon R, Lemire C, Begin P, Carr S et al Egg-allergic patients can be safely vaccinated against infl uenza J Allergy Clin
Immunol. 2012 Nov;130(5):1213-1216.
Gaston De Serres, Marie-Claude Gariépy, Brenda Coleman, Isabelle Rouleau, Shelly McNeil, Mélanie Benoît, Allison McGeer, Ardith Ambrose, Judy
Needham, Chantal Bergeron, Cynthia Grenier, Kenna Sleigh, Arlene Kallos, Manale Ouakki, Najwa Ouhoummane, Grant Stiver, Louis Valiquette,
Anne McCarthy, Julie Bettinger, on behalf of the PHAC-CIHR infl uenza Research Network (PCIRN) Short and Long-Term Safety of the 2009 AS03-
Adjuvanted Pandemic Vaccine. Research Article | published 03 Jul 2012 | PLOS ONE 10.1371/journal.pone.0038563
RLN Reference Laboratory Network
Kuster SP, Coleman BL, Raboud J, McNeil S, De Serres G, Gubbay J, Hatchette T, Katz KC, Loeb M, Low D, Mazzulli T, Simor A, McGeer AJ, for
the Working Adult Infl uenza Cohort Study Group. Acute Care Hospital Workers and Risk of Infl uenza Infection during the 2009 H1N1 Infl uenza
Pandemic. 2013 Emerg Infect Dis (in press)
Karen K. Yam, Jyotsana Gupta, Elizabeth Allen, Brian Ward. Adjuvanted infl uenza vaccines in young and aged BALB/c mice. Poster. European
Congress of Immunology,Glasgow, Scotland, 5-8 September, 2012.
Katie Young , Manon Couture , Marc-André D’aoust , Nathalie Landry, Louis Vézina , and Brian Ward.. Innate and adaptive immune responses to
plant-based H5 VLP by murine splenocytes. Poster. European Congress of Immunology, Glasgow, Scotland, 5-8 September, 2012.
Katie Young, Manon Couture , Marc-André D’aoust , Nathalie Landry Louis Vézina, and Brian Ward . Innate and adaptive immune responses to
plant-based H5 VLP by murine splenocytes. Poster . Canadian Immunization Conference Dec 2-5, 2012.
Wisner, A. L. S., LeBlanc, J., Hatchette, T., El-Sherif, M., and McNeil, S. Molecular Detection of Streptococcus pneumoniae in Nasopharyngeal Swabs
and Deduction of Serotypes by PCR. 10th Canadian Immunization Conference, , Vancouver, BC, Canada, Dec 2-5, 2012.
Wisner, A. L. S., LeBlanc, J., Hatchette, T., El-Sherif, M., and McNeil, S for the PCIRN Serious Outcomes Surveillance Network Investigators.
Molecular Detection of Streptococcus pneumoniae in Nasopharyngeal Swabs and Deduction of Serotypes by Polymerase Chain Reaction (PCR).
Presentation. ID Research Day, Halifax, NS, Canada, April 23-24, 2012
Yam KK, Gupta J, Brewer A, Scheifele DW, Halperin S, Ward BJ, and PCIRN (Public Health Agency of Canada-Canadian Institute of Health
Research Infl uenza Research Network). 2012. Unusual patterns of IgG avidity in some young children following two doses of adjuvanted
pandemic H1N1(2009) infl uenza vaccine. Clin Vaccine Immunol 2013
Wisner, A. L. S., LeBlanc, J., Hatchette, T., El-Sherif, M., and McNeil, S. Molecular Detection of Streptococcus pneumoniae in Nasopharyngeal Swabs
and Deduction of Serotypes by PCR submitted abstract for AMMI CACMID Annual Conference, Quebec City, QC, Canada, April 4-6 2013,.
MacRae C, LeBlanc JJ, McNeil SA, Hatchette TF. Determination of the viral etiology and epidemiology of infl uenza-negative patients with acute
respiratory disease. (Dalhousie ID research day 2014; and IWK summer studentship 2013 – winner of best research project
Ward BJ, Hatchette TF and the other members of the PCIRN Reference Laboratories. Why is lab testing for infl uenza so diffi cult? PCIRN annual
meeting, Toronto. May 27, 2013 (oral presentation)
Lang A, LeBlanc J, Hatchette T, ElSherif M, McNeil S, on behalf of the PCIRN Serious Outcomes Surveillance Network investigators. Molecular
detection of streptococcus pneumonia in nasopharyngeal swabs and deduction of “sero”types by polymerase chain reaction (PCR). PCRIN annual
meeting, Toronto. May 27, 2013. (oral presentation)
Yam K. Long-term immune responses to AS03-adjuvanted, low antigen does infl uenza vaccine in BALB/c mice. PCIRN annual meeting, Toronto.
May 27, 2013. (oral presentation).
Yam KK, Gupta J, Brewer A, Scheifele DW, Halperin S, Ward BJ; Public Health Agency of Canada/Canadian Institute of Health Research, Infl uenza
Research Network (PCIRN) Rapid Trial Study 3 (RT-03) Investigators. Unusual patterns of IgG avidity in some young children following two doses
of the adjuvanted pandemic H1N1 (2009) infl uenza virus vaccine. Clin Vaccine Immunol. 2013 Apr;20(4):459-67
Pizzorno A, Abed Y, Bouhy X, Boivin G. Identifi cation of a permissive mutation restoring the fi tness of the H275Y Oseltamavir resistance mutation
in 2009 pandemic infl uenza A/H1N1 viruses. PCIRN annual meeting, Toronto. May 27, 2013. (poster)
Retamal M., Abed Y., Corbeil J. and Boivin G. Development of monoclonal antibodies against infl uenza A (H1N1)pdm09 surface proteins. PCIRN
annual meeting, Toronto. May 27, 2013. (poster)
Young K, Vézina L, Couture M, Arthus-Cartier G, Ward B. Plant-derived infl uenza H5-based virus-like particles preferentially associate with innate
phagocytic cells. PCIRN annual meeting, Toronto. May 27, 2013. (poster)
Young K, Couture M, D’Aoust MA, Landry N, Ward BJ. Generation and characterization of a plant-made infl uenza H5 virus-like particle containing
eGFP. (2014 submitted)
Yam K, Mallet C, Burt D, Ward BJ. Immune responses to extreme low-dose infl uenza antigen adjuvanted with AS03 in a BALB/c mouse model
(submitted 2014)
Retamal, M. Abed, Y., Corbeil, J., Boivin, G. Epitope mapping of the 2009 pandemic and the A/Brisbane/59/2007 seasonal (H1N1) infl uenza
virus haemagglutinins using mAbs and escape mutants. J Gen Virol. 2014 Nov;95(Pt 11):2377-89. doi: 10.1099/vir.0.067819-0. Epub 2014 Jul
30.
Retamal, M. et al. Heterosubtyic Protection Conferred by the Human Monoclonal Antibody PN-SIA28 Against Infl uenza A Lethal Infections in Mice.
Submitted to the journal Antimicrobial Agents and Chemotherapy.
Hatchette TF, Scholz H, Bolotin S, Crowcroft N, Jackson C, McLachlan E, Severini A; on behalf of the Immunity of Canadians and Risk of Epidemics
(iCARE) laboratory group and the Canadian Immunization Research Network (CIRN). Correlation Of The BioPlex Test and Plaque Reduction
Neutralization Test For Determining Antibody Immunity To Measles Virus. Poster presentation. Canadian Immunization Conference, 2014. Ottawa,
ON. Dec 3, 2014.
2015 ANNUAL REPORT 19
