Serious Outcomes Surveillance (SOS) Network

The Serious Outcomes Surveillance Network (SOS) is comprised of more than 15 hospitals in 5 provinces. While primarily focused on describing the burden of influenza and influenza vaccine effectiveness against severe disease, the SOS network has also leveraged industry funding to measure the burden of invasive meningococcal disease, community-acquired pneumonia, and invasive pneumococcal diseases in adults. Along with Canada’s Immunization Monitoring Program ACTive (IMPACT) pediatric surveillance network, the SOS network will provide CIRN with hospital-based surveillance and vaccine effectiveness capability across the full age spectrum.

In addition to ongoing surveillance activities, SOS has conducted specialized supplemental studies that have strengthened the robustness of the ongoing assessments of vaccine effectiveness estimated by the test-negative case control method, better defined influenza burden of disease, and enhanced the capacity of the network to rapidly respond to emerging vaccine safety signals.